Results 41 to 50 of about 83,883,403 (289)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Fast interior point solution of quadratic programming problems arising from PDE-constrained optimization [PDF]
, 2017 Interior point methods provide an attractive class of approaches for solving linear, quadratic and nonlinear programming problems, due to their excellent efficiency and wide applicability.
Gondzio, Jacek +4 more
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Radial basis function based meshless methods for fluid flow problems
, 2006 This thesis is concerned with the development of meshless methods using radial basis functions for solving fluid flow problems. The advantage of meshless methods over traditional mesh-based methods is that they make use of a scattered set of collocation ...
Chinchapatnam, Phani P.
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A variable neighborhood search with an effective local search for uncapacitated multilevel lot-sizing problems [PDF]
, 2014 In this study, we improved the variable neighborhood search (VNS) algorithm for solving uncapacitated multilevel lot-sizing (MLLS) problems. The improvement is two-fold.
Xu, Yuchun +4 more
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Marketing methods for solving management problems of higher educational institutions
Наукові Записки Наукма: Соціологія, 2018 Educational management is a complex, hierarchically organized structured subsystem of the general education system, able to provide its performance and development while maintaining the basic quality parameters using social technologies of developmental ...
Yana Dubinina
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Finite element methods for incompressible flow problems
, 2016 This book explores finite element methods for incompressible flow problems: Stokes equations, stationary Navier-Stokes equations, and time-dependent Navier-Stokes equations.
John, Volker
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Some methods for solving boundary value problems for polyharmonic equations
Қарағанды университетінің хабаршысы. Математика сериясыThis article consists of three sections. In the first section the concept of Vekua space is introduced, where for elliptic systems of the first order, the theorem on the representation of the solution of a homogeneous equation and the theorem on the ...
M.T. Sabirzhanov +3 more
doaj +1 more source