Results 91 to 100 of about 1,049,189 (292)
On-orbit damage detection and health monitoring of large space trusses: Status and critical issues [PDF]
The long lifetimes, delicate nature and stringent pointing requirements of large space structures such as Space Station Freedom and geostationary Earth sciences platforms might require that these spacecraft be monitored periodically for possible damage ...
Kashangaki, Thomas A. L.
core +1 more source
Wicked but worth it: student perspectives on socio-hydrology [PDF]
, 2016 harvestPolicy AnalysisMulti Actor ...
Bach +36 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Rivers of the Anthropocene, Phase 1: A Comparative Study of the Ohio and Tyne River Systems [PDF]
, 2013 poster abstractRivers of the Anthropocene” addresses a fundamental problem facing scholars and policy makers alike: despite important advances in our understanding of the earth as a system — one in which humans and human systems have become recognized as
Kelly, Jason M. +2 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Multi-sensory Integration for a Digital Earth Nervous System [PDF]
, 2014 The amount of geospatial data is increasing, but interoperability issues hinder integrated discovery, view and analysis. This paper suggests an illustrative and extensible solution to some of the underlying challenges, by extending a previously suggested
OSTERMANN Frank, SCHADE SVEN
core
Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
An acoustic view of ocean mixing [PDF]
, 2010 Knowledge of the parameter K (turbulent diffusivity/"mixing intensity") is a key to understand transport processes of matter and energy in the ocean. Especially the almost vertical component of K across the ocean stratification (diapycnal diffusivity ...
Banyte, Donata +4 more
core