Results 111 to 120 of about 119,491,879 (244)

Editor di Hydrology and Earth System Sciences (Impact Factor 3.587 in 2012)

, 2013
Hydrology and Earth System Sciences (HESS) is an international two-stage open access journal for the publication of original research in hydrology, placed within a holistic Earth System Science context.
MONTANARI, ALBERTO
core   +1 more source

UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2014)

, 2014
University of Minnesota Duluth. Department of Earth and Environmental Sciences. (2014). UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2014).
University of Minnesota Duluth. Department of Earth and Environmental Sciences
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A systematic map of methods for assessing societal benefits of Earth science information

Proceedings of the National Academy of Sciences
Remotely sensed Earth science information (ESI) has become increasingly central to addressing global challenges, yet its societal value, i.e., the difference ESI makes in real-world decisions and outcomes, is rarely quantified. In this study, we systematically map peer-reviewed literature that explicitly assesses the societal value of ESI across ...
Casey C. O’Hara, Mabel Baez-Schon, Rebecca Chaplin-Kramer, Samantha H. Cheng, Alejandra Echeverri, Gillian L. Galford, Rachelle K. Gould, Cristina L. Mancilla, Maura C. Muldoon, Gerald G. Singh, Priscilla Baltezar, Yusuke Kuwayama, Stephen Polasky, Amanda D. Rodewald, Richard P. Sharp, Elizabeth J. Tennant, Jiaying Zhao, Benjamin S. Halpern   +17 more
openaire   +2 more sources

UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2017)

, 2017
University of Minnesota Duluth. Department of Earth and Environmental Sciences. (2017). UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2017).
University of Minnesota Duluth. Department of Earth and Environmental Sciences
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2016)

, 2016
University of Minnesota Duluth. Department of Earth and Environmental Sciences. (2016). UMD Earth and Environmental Sciences Newsletter for Alumni & Friends (2016).
University of Minnesota Duluth. Department of Earth and Environmental Sciences
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source