Results 111 to 120 of about 168,021 (301)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Bactericidal activities of woven cotton and nonwoven polypropylene fabrics coated with hydroxyapatite-binding silver/titanium dioxide ceramic nanocomposite "Earth-plus"

International Journal of Nanomedicine, 2011
Eriko Kasuga1,2, Yoshiyuki Kawakami2,3, Takehisa Matsumoto1, Eiko Hidaka1, Kozue Oana2, Naoko Ogiwara1, Dai Yamaki4, Tsukasa Sakurada4, Takayuki Honda1,51Department of Laboratory Medicine, Shinshu University Hospital, 2Division of Infection Control and ...
Kasuga E, Kawakami Y, Matsumoto T, Hidaka E, Oana K, Ogiwara N, Yamaki D, Sakurada T, Honda  T   +8 more
doaj  

Report of the Dry Valley Drilling Project, 1974-75

Antarctic Record, 1976
The Japanese researches participated with the Dry Valley Drilling Project (DVDP) in the McMurdo Sound region during the 1974-75 austral summer season. This project was jointly organized by New Zealand, the United States of America and Japan. The Japanese
Katsutada KAMINUMA, Tetsuya TORII, Hajime KURASAWA, Kikuo KATO, Osamu WAGURI   +4 more
doaj   +1 more source

The Scientific Method and Earth Sciences [PDF]

Journal of Energy Resources Technology, 2006
Larry W. Lake, Steven L. Bryant
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Assessment on the feasibility of future shepherding of asteroid resources [PDF]

, 2012
Most plausible futures for space exploration and exploitation require a large mass in Earth orbit. Delivering this mass requires overcoming the Earth’s natural gravity well, which imposes a distinct obstacle to any future space venture.
Sanchez Cuartielles, Joan-Pau, McInnes, Colin, Sanchez, J.P., McInnes, C.R.   +3 more
core   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source