Results 121 to 130 of about 1,049,189 (292)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Optical Mineralogy in a Modern Earth Sciences Curriculum [PDF]
, 2007 Provides pedagogical insight concerning the skill of studying minerals The resource being annotated is: http://www.dlese.org/dds/catalog_SERC-NAGT-000-000-000-651 ...
Lamont-Doherty Earth Observatory, Columbia University
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
MetalsRare earth elements (REEs) and Sc are concentrated in aluminum production byproducts. The novel REEs recovery approach, which involves leaching with acid at a pH > 3 in the presence of MgSO4, results in the formation of a pregnant leach solution (PLS ...
Julia Napol’skikh +4 more
doaj +1 more source
Improvements of the gravity field from satellite techniques as proposed to the European Space Agency [PDF]
, 1978 A summary of the European Earth Sciences Space Programme and the requirements for each gravity field mapping resulting from this programme are given. Three satellite experiments for gravity field improvement proposed to the European Space Agency in the ...
Reigber, C.
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Transfer orbit stage mechanisms thermal vacuum test [PDF]
A systems level mechanisms test was conducted on the Orbital Sciences Corp.'s Transfer Orbit Stage (TOS). The TOS is a unique partially reusable transfer vehicle which will boost a satellite into its operational orbit from the Space Shuttle's cargo bay ...
Oleary, Scott T.
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Advancements in the Measurement of the Cryosphere Using Geophysics — Introduction [PDF]
, 2016 Frozen regions of the earth are known as the cryosphere. The arctic, Antarctica, permafrost, ice sheets, and glaciers are some of the most challenging places to measure subsurface parameters, but they can also be some of the most important places to ...
Arcone, Steven +4 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Activities of the Space Advanced Research Team at the University of Glasgow [PDF]
, 2008 A wide range of technologies and methodologies for space systems engineering are currently being developed at the University of Glasgow. Much of the work is centred on mission analysis and trajectory optimisation, complemented by research activities in ...
Radice, G., Vasile, M.
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