Results 21 to 30 of about 896,359 (265)

whoishRisk – an R package to calculate WHO/ISH cardiovascular risk scores for all epidemiological subregions of the world [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The World Health Organisation and International Society of Hypertension (WHO/ISH) cardiovascular disease (CVD) risk assessment charts have been implemented in many low- and middle-income countries as part of the WHO Package of Essential Non-Communicable ...
Dylan Collins, Joseph Lee, Niklas Bobrovitz, Constantinos Koshiaris, Alison Ward, Carl Heneghan   +5 more
doaj   +1 more source

Defining decision thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision (EtD) frameworks: a protocol for a randomised methodological study (GRADE-THRESHOLD)

BMJ Open, 2022
Introduction The Grading of Recommendations Assessment, Development and Evaluation (GRADE) and similar Evidence to Decision (EtD) frameworks require its users to judge how substantial the effects of interventions are on desirable and undesirable people ...
Pablo Alonso-Coello, Lawrence Mbuagbaw, Elena Parmelli, Feng Xie, Holger J Schünemann, Antonio Bognanni, Nancy Santesso, Wojtek Wiercioch, Elie A Akl, Thomas Piggott, Uwe Siebert, Ilse M Verstijnen, Andrea J Darzi, Jan L Brozek, Gian Paolo Morgano, Zuleika Saz-Parkinson   +15 more
doaj   +1 more source

Prevalence of primary outcome changes in clinical trials registered on ClinicalTrials.gov: a cross-sectional study [v1; ref status: indexed, http://f1000r.es/34l]

F1000Research, 2014
Background: An important principle in the good conduct of clinical trials is that a summary of the trial protocol, with a pre-defined primary outcome, should be freely available before the study commences.
Sreeram Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi, Michelle Klingel, Daniel Magnus, Julia Pakpoor, Ben Goldacre   +6 more
doaj   +1 more source

Whose sample is it anyway? Widespread misannotation of samples in transcriptomics studies [version 2; referees: 2 approved]

F1000Research, 2016
Concern about the reproducibility and reliability of biomedical research has been rising. An understudied issue is the prevalence of sample mislabeling, one impact of which would be invalid comparisons.
Lilah Toker, Min Feng, Paul Pavlidis
doaj   +1 more source

Whose sample is it anyway? Widespread misannotation of samples in transcriptomics studies [version 1; referees: 2 approved]

F1000Research, 2016
Concern about the reproducibility and reliability of biomedical research has been rising. An understudied issue is the prevalence of sample mislabeling, one impact of which would be invalid comparisons.
Lilah Toker, Min Feng, Paul Pavlidis
doaj   +1 more source

Case Report: A case report of unstable Hangman fracture in a eighty year old male [version 2; referees: 2 approved, 1 not approved]

F1000Research, 2015
Herein we discuss a rare variant of hangman’s fracture in an eighty year old male with good Karnofsky performance score. We performed X-ray and magnetic resonance imaging (MRI) of the cervical spine to confirm the diagnosis.
Sunil Munakomi, Binod Bhattarai
doaj   +1 more source

Blinding in trials of interventional procedures is possible and worthwhile [version 2; referees: 3 approved]

F1000Research, 2018
In this paper, we use evidence from our earlier review of surgical randomised controlled trials with a placebo arm to show that blinding in trials of interventional procedures is feasible.
Karolina Wartolowska, David Beard, Andrew Carr   +2 more
doaj   +1 more source

Feature determination from powered wheelchair user joystick input characteristics for adapting driving assistance [version 3; referees: 2 approved]

Wellcome Open Research, 2018
Background: Many powered wheelchair users find their medical condition and their ability to drive the wheelchair will change over time. In order to maintain their independent mobility, the powered chair will require adjustment over time to suit the user ...
Michael Gillham, Matthew Pepper, Steve Kelly, Gareth Howells   +3 more
doaj   +1 more source

Developing WHO guidelines: Time to formally include evidence from mathematical modelling studies [version 2; referees: 2 approved]

F1000Research, 2018
In recent years, the number of mathematical modelling studies has increased steeply. Many of the questions addressed in these studies are relevant to the development of World Health Organization (WHO) guidelines, but modelling studies are rarely formally
Matthias Egger, Leigh Johnson, Christian Althaus, Anna Schöni, Georgia Salanti, Nicola Low, Susan L. Norris   +6 more
doaj   +1 more source

Blinding in trials of interventional procedures is possible and worthwhile [version 1; referees: 3 approved]

F1000Research, 2017
In this paper, we have used evidence from our earlier review of surgical randomised controlled trials with a placebo arm to show that blinding in trials of interventional procedures is feasible, and that many creative methods can be used to make the ...
Karolina Wartolowska, David Beard, Andrew Carr   +2 more
doaj   +1 more source