Results 61 to 70 of about 170,711,090 (240)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Identification of methicillin-resistant Staphylococcus aureus within the Nation’s Veterans Affairs Medical Centers using natural language processing

BMC Medical Informatics and Decision Making, 2012
Background Accurate information is needed to direct healthcare systems’ efforts to control methicillin-resistant Staphylococcus aureus (MRSA). Assembling complete and correct microbiology data is vital to understanding and addressing the multiple drug ...
Jones Makoto, DuVall Scott L, Spuhl Joshua, Samore Matthew H, Nielson Christopher, Rubin Michael   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Analysis of Multimodal Data in Project Management: Prospects for Using Machine Learning

Управленческие науки
The modern project environment is characterized by high complexity, uncertainty, speed and depth of changes that affect the project during its life cycle.
P. A. Mikhnenko
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Model of identification and prediction of building design defects on the basis of its inspection results (rus) [PDF]

Инженерно-строительный журнал, 2011
Known methods of definition the reasons of building designs damages not to the full consider possibilities of expert estimations of their inspection results.
Soldatenko T.N.
doaj  

Development of the technique of evaluating the professionalism of young pharmacists as a basic component of their social responsible behavior

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
The aim of the work is to develop a methodology for assessing the professionalism of the modern young pharmacist as the main component of his socially responsible behavior, as well as to verify the reliability and validity.
N. О. Tkachenko, B. Р. Hromovyk, L. N. Serhieieva   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

PreMedOnto: A Computer Assisted Ontology for Precision Medicine [PDF]

, 2019
This paper proposes an ontology learning framework that combines text mining, information extraction and retrieval. The proposed model takes advantage of existing structured knowledge by reusing terms and concepts from other ontologies.
Tawfik, N., Spruit, M., Métais, et al., E., Organization and Information, Natural Language Processing, Sub Organization and Information, Sub Natural Language Processing, Noha S. Tawfik, Marco R. Spruit   +8 more
core   +2 more sources

Use of the self-organising map network (SOMNet) as a decision support system for regional mental health planning

Health Research Policy and Systems, 2018
Background Decision-making in mental health systems should be supported by the evidence-informed knowledge transfer of data. Since mental health systems are inherently complex, involving interactions between its structures, processes and outcomes ...
Younjin Chung, Luis Salvador-Carulla, José A. Salinas-Pérez, Jose J. Uriarte-Uriarte, Alvaro Iruin-Sanz, Carlos R. García-Alonso   +5 more
doaj   +1 more source