Results 101 to 110 of about 1,481 (212)

The Effect of Reliability Index Values on Resulting Reliability-Based Topology Optimization Configurations: Numerical Validation by Shape Optimization

Инженерные технологии и системы, 2019
Introduction. The classical topology optimization leads to structural type and general layout prediction and gives a rough description of the shape of both the external and internal structure boundaries.
Ghias Kharmanda, Imad R. Antypas, Alexey G. Dyachenko   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Distributed Newton-Type Methods with Communication Compression and Bernoulli Aggregation

, 2022
Despite their high computation and communication costs, Newton-type methods remain an appealing option for distributed training due to their robustness against ill-conditioned convex problems.
Qian, Xun, Richtarik, Peter, Islamov, Rustem, Hanzely, Slavomir, Safaryan, Mher   +4 more
core  

A correlation analysis-based federated learning framework for defending against collusion-free-riding attacks

Cybersecurity
Federated learning (FL) is a type of distributed machine learning that enables multiple participants to collaboratively build machine learning models without transferring data outside their local devices, thereby ensuring data privacy and security ...
MeiTing Xue, Hao Zhong, Yukun Shi, Yan Zeng, Jilin Zhang, Nailiang Zhao   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A study of the turbulent wake of an airfoil in an air stream with a 90° curvature using hot-wire anemometry and large eddy simulation

, 2008
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The broad aim of the work presented in this thesis is to investigate the wake of an airfoil under the combined effects of streamwise curvature and pressure ...
Farsimadan, Ehsaan
core  

The Effect of Ge Doping on α-Ag₂S’s Thermoelectric and Mechanical Properties

Inorganics
Thermoelectric materials are capable of generating electrical energy in response to a temperature gradient. Non-renewable energy resources are depleting, so the development of renewable energy sources that are environmentally sustainable is essential ...
Gabriela Hrickova, Frantisek Mihok, Zuzana Molcanova, Beata Ballokova, Wanda Mamrilla, Robert Dzunda, Peter Lukacs, Alena Pietrikova, Karel Saksl   +8 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source