Results 81 to 90 of about 167,180,107 (247)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Optimum design of reinforced concrete rectangular columns subjected to axial compression and biaxial bending moments [PDF]
, 2015 This study investigates the optimum design in terms of the minimum cost of reinforced concrete rectangular columns subjected to axial compression force and biaxial bending moments about x and y axes.
Mohammad, FA, Seyan, DA
core
Explicit Numerov type methods with reduced number of stages [PDF]
, 2003 We present in this paper a new approach for the derivation of hybrid explicit Numerov type methods. The new methodology does not require the intermediate use of high accuracy interpolatory nodes, since we only need the Taylor expansion of the internal ...
Tsitouras, Ch
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
HeliyonThis research addresses the gap in efficient thawing methods by investigating the effects of ohmic thawing variables and freezing methods on the thawing speed and quality attributes of ground turkey breast, aiming to identify the optimal ohmic thawing ...
Shabnam Safari +2 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundInterstage mortality (IM) remains significant after stage 1 palliation (S1P) for single‐ventricle heart disease (SVD), with many deaths sudden and unexpected.
David W. Brown +11 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Frontiers in Plant ScienceThe process of obtaining greater mechanistic insight into important traits that follows the linking of a gene to a trait can be impeded if the encoded protein has no known biochemical function or a vague biochemical function.
Lingling Zhu, Robert M. Larkin
doaj +1 more source
Assessing phytase activity–methods, definitions and pitfalls. [PDF]
, 2015 Phytases are nutritionally important for increased bioavailability of dietary minerals and phosphate for monogastric animals including humans. Release of minerals and phosphate is accomplished by the enzymatic stepwise degradation of phytate (inositol ...
Carlsson, Nils-Gunnar +5 more
core +1 more source