Results 71 to 80 of about 174,537,063 (257)

Bone mineral density and hip migration index in children with spinal muscular atrophy: a cross-sectional analysis 2024–2026 – report [PDF]

Chirurgia Narządów Ruchu i Ortopedia Polska
Introduction. Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder in which primary motor neuron degeneration is accompanied by secondary skeletal complications, including impaired bone mineralisation and hip instability.
Marek Jóźwiak, Amadeusz Brzykcy, Sabina Brazevic, Magdalena Ratajczyk, Paweł Chmara, Patrycja Sakowska, Przemysław Daroszewski, Radosław Rutkowski   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Optical studies of the low velocity gradient type Ia supernovae 2009an and 2009ig

, 2011
UBVRI photometry and medium resolution spectroscopy of two Type Ia supernovae, SN 2009an and SN 2009ig, are presented. Their Δm15(B) indicate these two SNe marginally deviate from “normal” Type Ia events.
Anupama, G. C., Anto, P., Sahu, D. K., Gurugubelli, U. K.   +3 more
core   +1 more source

Rapid deployment valve system shortens operative times for aortic valve replacement through right anterior minithoracotomy

Journal of Cardiothoracic Surgery, 2017
Background There is growing evidence from the literature that right anterior minithoracotomy aortic valve replacement (RAT-AVR) improves clinical outcome.
Constanze Bening, Khaled Hamouda, Mehmet Oezkur, Christoph Schimmer, Ina Schade, Armin Gorski, Ivan Aleksic, Rainer Leyh   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Development of detection method for the generating state of maximun friction force on CVT belt

Nihon Kikai Gakkai ronbunshu, 2019
Vehicles with a metal belt-type continuously variable transmission(CVT) that can run under optimal engine fuel consumption conditions have been popular. However, the CVT unit itself can improve in terms of the efficiency. This is possible as the clamping
Hiroyuki YAMAGUCHI, Hiroyuki NISHIZAWA, Masataka OSAWA, Keisuke NINOMIYA   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Reduced density gradient isosurface and residue type of Lhβ-defensin dimer.

, 2016
(A) Reduced density gradient isosurface map between Arg54 and Tyr32 in dimeric structure of Lhβ-defensin created by Multiwfn software [36]. The blue, red and green (or earth green) colors indicate the strong attractive, strong repulsive and van der Waals
Fancui Meng (693986), Chenglung Chen (2847515), Rong Shao (202747), Qihuan Zhang (2847518), Zhitao Qi (2847512), Wei Xu (28953)   +5 more
core   +1 more source

Crack inhibition and crystallographic texture control in an additively manufactured IN738LC Ni-based superalloy

Journal of Materials Research and Technology
The additive manufacturing of directionally solidified Ni-based superalloys remains a significant challenge due to the formation of stray equiaxed grains and their high susceptibility to cracking, particularly for high-volume γ´-type Ni-based superalloys.
Fangxian Zhang, Liping Zhou, Xinliang Xie, Zhenbo Zhang, Qi Chao, Guohua Fan   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source