Results 51 to 60 of about 174,537,063 (257)

Machine learning uncovers previously undetectable genetic deletions in cancer panel sequencing

npj Precision Oncology
Missed genetic deletions can prevent cancer patients from receiving effective targeted therapy. Standard pipelines, such as TSO500, use bin count averaging for copy number variation detection but often overlook focal events. To address this, we developed
Irina A. Kerle, Oleksandr Husak, Thomas Gross, Andreas Hartig, Rebecca Prause, Daniela Richter, Sascha Brückmann, Maximilian Werner, Anja Kögler, Dorothea Hanf, Lino Möhrmann, Doreen William, Karsten Wendt, Nicole Pfarr, Carolin Mogler, Daniela E. Aust, Evelin Schröck, Christoph Heining, Hanno Glimm   +18 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

On the Line-Search Gradient Methods for Stochastic Optimization

, 2020
We consider several line-search based gradient methods for stochastic optimization: a gradient and accelerated gradient methods for convex optimization and gradient method for non-convex optimization.
Dvurechensky, Pavel, Dvinskikh, Darina, Ogaltsov, Aleksandr, Spokoiny, Vladimir, Gasnikov, Alexander, Pavel Dvurechensky, Alexander Gasnikov, Vladimir Spokoiny, Aleksandr Ogaltsov, Darina Dvinskikh   +9 more
core   +1 more source

Gradient pursuits [PDF]

, 2008
Sparse signal approximations have become a fundamental tool in signal processing with wide ranging applications from source separation to signal acquisition.
Blumensath, T., Davies, Michael; id_orcid, Davies, M.E.   +2 more
core   +1 more source

Locking free and gradient robust H(div)-conforming HDG methods for linear elasticity [PDF]

, 2020
Robust discretization methods for (nearly-incompressible) linear elasticity are free of volume-locking and gradient-robust. While volume-locking is a well-known problem that can be dealt with in many different discretization approaches, the concept of ...
Streckenbach, Timo, Linke, Alexander, Fu, Guosheng, Lehrenfeld, Christoph, Christoph Lehrenfeld, Guosheng Fu, Timo Streckenbach, Alexander Linke   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

DPI-TD3: Data-Driven Evasive Maneuver Strategy for Adaptive Control of Exo-Atmospheric Vehicles

Mathematics
In the context of evasive maneuvering for exo-atmospheric vehicles, reinforcement learning and other data-driven decision-making techniques have been explored extensively.
Yuzhe Wang, Bing He, Shiyu Cai, Honglan Huang, Xianyang Zhang, Zhelin Xu, Yu Lai, Qiang Hu   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Formulating reduced density gradient approaches for noncovalent interactions [PDF]

This work elucidates several forms of reduced electron density gradient (RDG) to describe non-covalent interactions (NCIs). By interpreting the RDG as a local-moment function, we systematically leveraged Weizacker\u27s and Fermi\u27s local moments.
Leandro, Ayarde-Henríquez, Cristian, Guerra, José , Burgos, Eduardo, Chamorro   +3 more
core   +1 more source