Results 51 to 60 of about 584,535 (262)

Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols [PDF]

, 2009
Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available.
Luceri, C., Castagnini, C., Martin, R., Evelo, C.T.; id_orcid, Zoetendal, E.G., Messerini, L., Eijssen, L., Caderni, G., Femia, A.P., Eijssen, L.M.; id_orcid, Renard, C.M., Giovannelli, L., Gaj, S., Evelo, C., Evelo, C.T., Bigagli, E., Baron, A., Toti, S., Lodovici, M., Salvadori, M., Dolara, P., Eijssen, L.M., Pitozzi, V.   +22 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An iterative methodology for REDIM reduced chemistry generation and its validation for partially-premixed combustion [PDF]

, 2023
Partially-premixed flames (PPFs) incorporate effects of both premixed and non-premixed types of reaction zones. The modelling of PPFs using manifold-based model reduction methods faces some inherent difficulties due to the underlying assumptions of a ...
Chunkan Yu (6801866), Prashant Shrotriya (17054270), Robert Schießl (11402076), Thorsten Zirwes (12240633), Ulrich Maas (6801875), Viatcheslav Bykov (6801872)   +5 more
core   +1 more source

DPI-TD3: Data-Driven Evasive Maneuver Strategy for Adaptive Control of Exo-Atmospheric Vehicles

Mathematics
In the context of evasive maneuvering for exo-atmospheric vehicles, reinforcement learning and other data-driven decision-making techniques have been explored extensively.
Yuzhe Wang, Bing He, Shiyu Cai, Honglan Huang, Xianyang Zhang, Zhelin Xu, Yu Lai, Qiang Hu   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration [PDF]

, 2010
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
Shah, Ajay M., Sven G. Meuth, de Angelis, MH, Henrike Grund, Schmidt, HHHW, Grund, Henrike, Schuhmann, M.K., Hrabě de Angelis, M., Sabine Meurer, Schuhmann, Michael, Schrewe, A., Stoll, G., Peter Kraft, Martin Hrabé de Angelis, Barit, David, Barit, D., Schwarz, Tobias, de Angelis, Martin Hrabe, Stoll, Guido, Shah, AM, Klopstock, T., Weissmann, N, Schrewe, A, Mittal, M, Herrmann, A.M., Jones, Emma, Schmidt, Harald, Konstanze Barthel, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Kraft, Peter, Becker, L., Fuchs, H, Jandeleit-Dahm, Karin, Anja Schrewe, Harald H. H. W, Herrmann, AM, David Barit, Sven G Meuth, Meurer, S., Weissmann, Norbert, Schmidt, H.H., Michael K. Schuhmann, Kraft, P., Armitage, Melanie, Schuhmann, Michael K., Weissmann, N., Meuth, SG, Schwarz, T, Karin Jandeleit-Dahm, Barthel, Konstanze, Herrmann, Alexander M., Stoll, G, Meurer, Sabine, Schmidt, Harald H. H. W., Guido Stoll, Wingler, K., Christian Geis, Mittal, Manish, Lore Becker, Schrewe, Anja, Klopstock, Thomas, Fuchs, Helmut, Shah, A.M., Jandeleit-Dahm, K, Gailus-Durner, V, Barthel, K., Ajay M. Shah, Klopstock, T, Manish Mittal, Armitage, Melanie E., Meuth, S.G., Shah, Ajay, Norbert Weissmann, Harald H. H. W. Schmidt, Kraft, P, Michael K Schuhmann, Hrabe ́ De Angelis, Grund, H, Meuth, Sven, Meuth, Sven G., Jones, E., Thomas Klopstock, Geis, C, Schuhmann, MK, Tobias Schwarz, Grund, H., Kleinschnitz, Christoph, Melanie E Armitage, Barthel, K, Meurer, S, Kleinschnitz, C, Fuchs, H., Armitage, ME, Kleinschnitz, C., Kirstin Wingler, Valérie Gailus-Durner, Geis, Christian, Geis, C., Jones, E, Karin J, Gailus-Durner, V., Emma Jones, Becker, L, Jandeleit-Dahm, Karin A., Wingler, Kirstin, Helmut Fuchs, Mittal, M., Schwarz, T., Armitage, M.E., Er M. Herrmann, Jandeleit-Dahm, K., Harald H H W Schmidt, Becker, Lore, Ajay M Shah, de Angelis, Martin, Christoph Kleinschnitz, Herrmann, Alexander, Alexander M. Herrmann, Wingler, K, Alexander M Herrmann, Melanie E. Armitage, Barit, D   +122 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Tryptophan-Tryptophan energy migration as a tool to follow apoflavodoxin folding [PDF]

, 2008
Submolecular details of Azotobacter vinelandii apoflavodoxin (apoFD) (un)folding are revealed by time-resolved fluorescence anisotropy using wild-type protein and variants lacking one or two of apoFD's three tryptophans.
Mierlo, C.P.M., van, Westphal, Adrie H., van Amerongen, H., Visser, N.V., Amerongen, H., van, van Hoek, Arie, Hoek, A., van, Visser, Antonie J.W.G., van Amerongen, Herbert, van Hoek, A., Visser, Nina V., Westphal, A.H., van Mierlo, Carlo P.M., Visser, A.J.W.G., van Mierlo, C.P.M.   +14 more
core   +1 more source

An ensemble approach for population mapping via remote and social sensing data fusion: considering building habitability and spatial heterogeneity

Geo-spatial Information Science
Remote sensing-derived building footprint data has been widely applied in population mapping. However, nonresidential buildings typically occupy larger areas or volumes, and obtaining building footprint data with type information is also a great ...
Yu Ma, Qin Huang, Manchun Li, Chen Zhou, Song Hua, Lu Sui   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source