Results 51 to 60 of about 167,180,107 (247)

The Gaia-ESO survey: Open clusters as tracers of galactic chemical evolution

Astronomy & Astrophysics
Aims. We investigate the formation and evolutionary trajectory of the Milky Way’s inner and outer galactic regions using stars from open clusters in the Gaia-ESO OC survey. Methods. Using numerical simulations from Chempy, we leveraged Markov chain Monte
Boucher K., Worley C. C., Gilmore G., Stonkutė E., Magrini L., Drazdauskas A., Bragaglia A., Tautvaišienè G., Bensby T., Jiménez-Esteban F., Martell S., Randich S., Damiani F.   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF

Journal of Ovarian Research
Background Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes.
Yang Liu, Yiran Zhao, Chengliang Zhou, Hong Zhu, Jiexue Pan, Jing Fu, Hefeng Huang, Hui Lin, Li Jin   +8 more
doaj   +1 more source

ESTUDO COMPUTACIONAL DA INFLUÊNCIA DE CO2 NO EMPILHAMENTO-π DE MONÔMEROS DE CORONENO SUBSTITUÍDOS COM ENXOFRE [PDF]

Química Nova
Asphaltenes are complex molecules with a tendency to aggregate. This property can be an issue for the oil industry due to CO2 reinjection into reservoirs to mitigate these gas emissions.
Kelly F. P. Laeber, Leticia M. Prates, Leonardo Baptista, Maurício T. M. Cruz   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Stochastic Variance-Reduced Policy Gradient [PDF]

, 2018
In this paper, we propose a novel reinforcement-learning algorithm consisting in a stochastic variance-reduced version of policy gradient for solving Markov Decision Processes (MDPs).
Pirotta, Matteo, Binaghi, Damiano, CANONACO, GIUSEPPE, PAPINI, MATTEO, Restelli, Marcello   +4 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Bone mineral density and hip migration index in children with spinal muscular atrophy: a cross-sectional analysis 2024–2026 – report [PDF]

Chirurgia Narządów Ruchu i Ortopedia Polska
Introduction. Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder in which primary motor neuron degeneration is accompanied by secondary skeletal complications, including impaired bone mineralisation and hip instability.
Marek Jóźwiak, Amadeusz Brzykcy, Sabina Brazevic, Magdalena Ratajczyk, Paweł Chmara, Patrycja Sakowska, Przemysław Daroszewski, Radosław Rutkowski   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source