Results 31 to 40 of about 1,481 (212)

Learning parameterized quantum circuits with quantum gradient

npj Quantum Information
Parameterized quantum circuits (PQCs) are crucial for quantum machine learning and circuit synthesis, enabling the practical implementation of complex quantum tasks. However, PQC learning has been largely confined to classical optimization methods, which
Keren Li, Yuanfeng Wang, Pan Gao, Shenggen Zheng   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Investigation of left ventricular changes according to valve type in patients with surgical replacement due to isolated aortic stenosis

, 2023
Objective: The aim of this study was to investigate postoperative left ventricular changes [left ventricular mass (LVM), left ventricular mass index (LVMI), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD ...
Isik, Mehmet, Ege, Erdal, Tanyeli, Oemer, Taban, Volkan Burak, Guener, Abdullah, Yildirim, Serkan   +5 more
core   +1 more source

Wasserstein GAN for moving differential privacy protection

Scientific Reports
Training machine learning models often requires large datasets, but using sensitive data for training poses risks of privacy leakage. Differentially private generative models can synthesize simulated data to prevent privacy breaches.
Enze Liu, Zhiguang Chu, Xing Zhang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Ensemble machine learning-based pre-trained annotation approach for scRNA-seq data using gradient boosting with genetic optimizer

BMC Bioinformatics
Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of gene expression by allowing researchers to analyze the transcriptomes of individual cells. This technology provides unprecedented insights into cellular heterogeneity, cellular states,
Osama Elnahas, Waleed M. Ead, Yushan Qiu, Jian Lu   +3 more
doaj   +1 more source

Improving the quality of payment fraud detection by using a combined approach of transaction analysis

Сучасний стан наукових досліджень та технологій в промисловості
Subject matter: The study focuses on the methods for detection fraud transactions. Goal: Improve the accuracy of machine learning models for fraud transactions with combined methods for transaction analysis. Tasks: Investigate methods of detection fraud
Світлана Гавриленко, Олексій Абдуллін   +1 more
doaj   +1 more source

Experimental and theoretical studies on (2E,5E)-2,5-bis(2-methoxybenzylidene)cyclopentanone: Structural, electrochemical, spectroscopic features, solid-state interactions, molecular docking and adsorption studies onto 2D carbon nanomaterials

Macedonian Journal of Chemistry and Chemical Engineering, 2023
A monocarbonyl analog of curcumin, (2E,5E)-2,5-bis(2-methoxybenzylidene)-cyclopentanone (B2MBCP), was prepared and characterized via spectroscopic methods (NMR, UV-Vis, FT-IR, and MS).
Veprim Thaçi, Arianit A. Reka, Nataša Ristovska, Ramiz Hoti, Avni Berisha, Jane Bogdanov   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source