Results 31 to 40 of about 167,180,107 (247)

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Learning parameterized quantum circuits with quantum gradient

npj Quantum Information
Parameterized quantum circuits (PQCs) are crucial for quantum machine learning and circuit synthesis, enabling the practical implementation of complex quantum tasks. However, PQC learning has been largely confined to classical optimization methods, which
Keren Li, Yuanfeng Wang, Pan Gao, Shenggen Zheng   +3 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Diffusion tensor imaging in anisotropic tissues: application of reduced gradient vector schemes in peripheral nerves

European Radiology Experimental
Background In contrast to the brain, fibers within peripheral nerves have distinct monodirectional structure questioning the necessity of complex multidirectional gradient vector schemes for DTI.
Olivia Foesleitner, Alba Sulaj, Volker Sturm, Moritz Kronlage, Fabian Preisner, Zoltan Kender, Martin Bendszus, Julia Szendroedi, Sabine Heiland, Daniel Schwarz   +9 more
doaj   +1 more source

Nonlinear Conjugate Gradient Methods with Wolfe Type Line Search [PDF]

, 2013
Nonlinear conjugate gradient method is one of the useful methods for unconstrained optimization problems. In this paper, we consider three kinds of nonlinear conjugate gradient methods with Wolfe type line search for unstrained optimization problems ...
Yuan-Yuan Chen, Shou-Qiang Du
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Wasserstein GAN for moving differential privacy protection

Scientific Reports
Training machine learning models often requires large datasets, but using sensitive data for training poses risks of privacy leakage. Differentially private generative models can synthesize simulated data to prevent privacy breaches.
Enze Liu, Zhiguang Chu, Xing Zhang
doaj   +1 more source

Experimental and theoretical studies on (2E,5E)-2,5-bis(2-methoxybenzylidene)cyclopentanone: Structural, electrochemical, spectroscopic features, solid-state interactions, molecular docking and adsorption studies onto 2D carbon nanomaterials

Macedonian Journal of Chemistry and Chemical Engineering, 2023
A monocarbonyl analog of curcumin, (2E,5E)-2,5-bis(2-methoxybenzylidene)-cyclopentanone (B2MBCP), was prepared and characterized via spectroscopic methods (NMR, UV-Vis, FT-IR, and MS).
Veprim Thaçi, Arianit A. Reka, Nataša Ristovska, Ramiz Hoti, Avni Berisha, Jane Bogdanov   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ensemble machine learning-based pre-trained annotation approach for scRNA-seq data using gradient boosting with genetic optimizer

BMC Bioinformatics
Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of gene expression by allowing researchers to analyze the transcriptomes of individual cells. This technology provides unprecedented insights into cellular heterogeneity, cellular states,
Osama Elnahas, Waleed M. Ead, Yushan Qiu, Jian Lu   +3 more
doaj   +1 more source