Results 61 to 70 of about 174,537,063 (257)

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth [PDF]

, 2009
OBJECTIVE: Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype.
Timpson, NJ, Ruokonen, A, Weedon, Michael N, Hattersley, AT, McCarthy, MI, Pouta, Anneli, Lindgren, Cecilia M, Perry, JR, Weedon, MN, Elliott, P, Groves, Christopher J, Smith, GD, Shields, B, Power, C, Järvelin, MR, Hyppönen, E, Shields, Beverley, Zeggini, Eleftheria, McCarthy, Mark I, Bennett, Amanda J, Ring, Susan M, Power, Chris, Ring, SM, Ruokonen, Aimo, Pouta, A, Strachan, DP, Elliott, Paul, Järvelin, Marjo-Riitta, Timpson, Nicholas J, Lango, Hana, Groves, CJ, Bennett, AJ, Hattersley, Andrew T, Lindgren, CM, Smith, George Davey, Zeggini, E, Frayling, Timothy M, Strachan, David P, Lango, H, Hyppönen, Elina, Freathy, RM, Perry, John R B, Frayling, TM, Freathy, Rachel M, Freathy, R.M., Hypponen, E., Hattersley, A.T., Shields, B., Ring, S.M., Bennett, A.J.   +49 more
core   +1 more source

An ensemble approach for population mapping via remote and social sensing data fusion: considering building habitability and spatial heterogeneity

Geo-spatial Information Science
Remote sensing-derived building footprint data has been widely applied in population mapping. However, nonresidential buildings typically occupy larger areas or volumes, and obtaining building footprint data with type information is also a great ...
Yu Ma, Qin Huang, Manchun Li, Chen Zhou, Song Hua, Lu Sui   +5 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The Gaia-ESO survey: Open clusters as tracers of galactic chemical evolution

Astronomy & Astrophysics
Aims. We investigate the formation and evolutionary trajectory of the Milky Way’s inner and outer galactic regions using stars from open clusters in the Gaia-ESO OC survey. Methods. Using numerical simulations from Chempy, we leveraged Markov chain Monte
Boucher K., Worley C. C., Gilmore G., Stonkutė E., Magrini L., Drazdauskas A., Bragaglia A., Tautvaišienè G., Bensby T., Jiménez-Esteban F., Martell S., Randich S., Damiani F.   +12 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF

Journal of Ovarian Research
Background Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes.
Yang Liu, Yiran Zhao, Chengliang Zhou, Hong Zhu, Jiexue Pan, Jing Fu, Hefeng Huang, Hui Lin, Li Jin   +8 more
doaj   +1 more source

ESTUDO COMPUTACIONAL DA INFLUÊNCIA DE CO2 NO EMPILHAMENTO-π DE MONÔMEROS DE CORONENO SUBSTITUÍDOS COM ENXOFRE [PDF]

Química Nova
Asphaltenes are complex molecules with a tendency to aggregate. This property can be an issue for the oil industry due to CO2 reinjection into reservoirs to mitigate these gas emissions.
Kelly F. P. Laeber, Leticia M. Prates, Leonardo Baptista, Maurício T. M. Cruz   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source