Results 101 to 110 of about 351,938 (393)
Model-based simulation of maintenance therapy of childhood acute lymphoblastic leukemia [PDF]
arXiv, 2019 Acute lymphoblastic leukemia is the most common malignancy in childhood. Successful treatment requires initial high-intensity chemotherapy, followed by low-intensity oral maintenance therapy with oral 6-mercaptopurine (6MP) and methotrexate (MTX) until 2-3 years after disease onset.
arxiv
Targeting of cytochrome b2 into the mitochondrial intermembrane space [PDF]
, 1993 Cytochrome b2 contains 2-fold targeting information: an amino-terminal signal for targeting to the mitochondrial matrix, followed by a second cleavable sorting signal that functions in directing the precursor into the mitochondrial intermembrane space ...
Guiard, Bernard +3 more
core
Disease activity and cognition in rheumatoid arthritis : an open label pilot study [PDF]
, 2012 Acknowledgements This work was supported in part by NIHR Newcastle Biomedical Research Centre. Funding for this study was provided by Abbott Laboratories.
Birchall, Daniel +6 more
core +1 more source
Gastroenterology, 2018 BACKGROUND & AIMS Parenteral methotrexate induces clinical remission but not endoscopic improvement of mucosal inflammation in patients with ulcerative colitis (UC). We performed a randomized, placebo-controlled trial to assess the efficacy of parenteral
H. Herfarth +26 more
semanticscholar +1 more source
Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease
Advanced Science, EarlyView.Improved reactive oxygen species scavenging capacities of functionalized micro/nanorobots (MNRs) are useful for the treatment of inflammatory bowel disease (IBD). MNRs can break the harmful bacteria in IBD, thereby eliminating inflammation and restoring the intestinal barrier function.
Ying Feng +5 more
wiley +1 more source
Methotrexate hepatotoxicity in patients with rheumatoid arthritis. [PDF]
, 2010 BACKGROUND Increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (MTX). The aim of this study, therefore was to evaluate the incidence of MTX induced hepatotoxicity and its risk ...
Akhlaghi, M +4 more
core
Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine [PDF]
, 2012 Introduction: The idiopathic inflammatory myopathies are rare diseases for which data regarding the natural history, response to therapies and factors affecting mortality are needed.
Crofford, Leslie J. +4 more
core +3 more sources
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure
, 2017 Rheumatoid arthritis (RA) is a common autoimmune inflammatory arthritis with a one percent prevalence worldwide. Left untreated, it leads to chronic progressive joint disease.
T. Mahajan, J. O'dell
semanticscholar +1 more source
British medical journal, 2016 Objective To compare methotrexate based disease modifying antirheumatic drug (DMARD) treatments for rheumatoid arthritis in patients naive to or with an inadequate response to methotrexate.
G. Hazlewood +5 more
semanticscholar +1 more source
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source