Results 101 to 110 of about 271,187 (352)
Advanced Science, EarlyView.This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen +8 more
wiley +1 more source
The Efficacy of Methotrexate-Impregnated Hydroxyapatite Composites on Human Mammary Carcinoma Cells
Journal of Orthopaedic Surgery, 2007 Purpose. To investigate the efficacy of local biodegradable composites of hydroxyapatite, plaster of Paris, and a binder of either alginate or chitosan impregnated with methotrexate on human mammary carcinoma cells. Methods.
J Vechasilp +3 more
doaj +1 more source
Biologic therapy with anti-TNFa in rheumathoid atrhritis
Reumatismo, 2011 Objective: To evaluate the efficacy, the tolerability, and treatment survival of the association of anti-TNFa (Infliximab, Etanercept, Adalimumab) plus Methotrexate vs Methotrexate as monotherapy in patients with reumathoid arthritis (RA).
G. Ferraccioli
doaj +1 more source
The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication
Advanced Science, EarlyView.Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li +9 more
wiley +1 more source
Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model. [PDF]
, 2020 Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in ...
Barreto, Natália +12 more
core +1 more source
Megaloblastic anaemia during methotrexate treatment of psoriasis. [PDF]
, 1966 Peter Borrie, Peter A. Clark
openalex +1 more source
Acta Dermato-Venereologica, 2018 Methotrexate treatment has been linked with an increased risk of melanoma. However, a possible dose-response relationship with respect to methotrexate exposure and melanoma has not been addressed.
Sam Polesie +3 more
doaj +1 more source
Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration
Advanced Science, EarlyView.This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li +11 more
wiley +1 more source
Studies of Sequential and Combination Antimetabolite Therapy in Acute Leukemia: 6-Mercaptopurine and Methotrexate [PDF]
, 1961 Emil Frei +20 more
openalex +1 more source