Results 101 to 110 of about 163,856 (309)

Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System—A Multicenter Cohort Study in 163 Patients

open access: yesAnnals of Neurology, EarlyView.
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospective, observational cohort study, we analyzed 163 adult patients who met the diagnostic criteria for PACNS.
Anna Lena Fisse   +29 more
wiley   +1 more source

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery

open access: yesAdvanced NanoBiomed Research, EarlyView.
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Methotrexate-induced leukoencephalopathy presenting as acute-onset limb weakness in a child: a case report

open access: yesJournal of Medical Case Reports
Background Methotrexate is an essential medicine used to treat childhood malignancies including acute lymphoblastic leukemia. Neurotoxicity manifesting as leukoencephalopathy is an important adverse effect of methotrexate.
Hashan Pathiraja   +5 more
doaj   +1 more source

Cerebellar medulloblastoma.Chemotherapeutic remission with vincristine cyclophosphamide and methotrexate [PDF]

open access: bronze, 1968
Sumner Hagler, Z Currimbhoy, M Tinsley
openalex   +1 more source

Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole‐Blood Transcriptomics Data

open access: yesArthritis &Rheumatology, EarlyView.
Objective Tumornecrosis factor inhibitors (TNFi) have significantly improved rheumatoid arthritis (RA) management, yet variability in patient response remains a substantial challenge, with approximately 40% of patients discontinuing TNFi due to nonresponse or adverse effects.
Chuan Fu Yap   +12 more
wiley   +1 more source

Lung Allografts in Dogs Treated with Methotrexate and Antilymphocyte Serum

open access: bronze, 1968
David A. Blumenstock   +3 more
openalex   +1 more source

Peripheral Blood Gene Expression Profiling and Prognostic Significance for the Course of Interstitial Lung Disease in Patients With Systemic Sclerosis

open access: yesArthritis &Rheumatology, EarlyView.
Objective We used data from the placebo arm of the Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial to determine the prognostic/predictive significance of peripheral blood cell (PBC) transcript modules for the course of forced vital capacity (FVC) in patients with systemic sclerosis–associated interstitial lung disease (SSc‐ILD ...
Shervin Assassi   +6 more
wiley   +1 more source

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