Results 101 to 110 of about 154,899 (297)

Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine

Journal of Pharmacological Sciences, 2019
The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats.
Yuho Takano, Megumi Hirano, Takuji Machida, Yusuke Obara, Naoya Hamaue, Kana Fujita, Masafumi Taniguchi, Tomoko Endo, Saki Shiga, Maiko Machida, Kenji Iizuka, Masahiko Hirafuji   +11 more
doaj  

Treatment of Chorionepithelioma with Methotrexate [PDF]

, 1962
Donald P. C. Chan
openalex   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

The Effect Of -401CT And -401CT Polymorphisms Of GGH Gene On Methotrexate Serum Level And Toxicity In Iranian Children With Acute Lymphoblastic Leukemia (ALL) Under Treatment In Ali Asghar Hospital In Tehran

پیاورد سلامت, 2015
Background and Aim: Acute lymphoblastic leukemia patients show differences in serum levels and toxicity associated with methotrexate after its treatment. Pharmacogenetics is an important determining factor for these differences. In this study, the effect
Abolfazl Kalantari, Farhad Zaker, Shahla Ansari Damavandi, Heydar Sharafi, Seyed Amir Yazdanparast   +4 more
doaj   +2 more sources

Megaloblastic anemia and methotrexate therapy. [PDF]

, 1966
J M Anderson, M. D. Smith, J Hutchison
openalex   +1 more source

Adverse events associated with monoclonal antibodies used for treatment of COVID‐19: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims This review aimed to synthesise the evidence related to the incidence of serious and non‐serious adverse events with the use of monoclonal antibodies (mAbs) among COVID‐19 patients. Methods Databases were searched from January 2020 to September 2023 for randomized clinical trials (RCTs) that used mAbs for the treatment of COVID‐19 regardless of ...
Htet Htet, Han You Kyung, Ismail Abdul Sattar Burud, Heethal Jaiprakash, Thiruselvi Subramaniam, Igor Iezhitsa, Renu Agarwal   +6 more
wiley   +1 more source

PREDICT‐GTN 1: Can we improve the FIGO scoring system in gestational trophoblastic neoplasia?

International Journal of Cancer, Volume 152, Issue 5, Page 986-997, 1 March 2023., 2023
What's new? The International Federation of Gynaecology and Obstetrics (FIGO) scoring system is used to predict resistance to first‐line single‐agent chemotherapy in gestational trophoblastic neoplasia (GTN) patients. HoweThis system is imperfect, however—one‐third of low‐risk patients develop resistance, and resistance rates increase with FIGO score ...
Victoria L. Parker, Matthew C. Winter, John A. Tidy, Barry W. Hancock, Julia E. Palmer, Naveed Sarwar, Baljeet Kaur, Katie McDonald, Xianne Aguiar, Kamaljit Singh, Nick Unsworth, Imran Jabbar, Allan A. Pacey, Robert F. Harrison, Michael J. Seckl   +14 more
wiley   +1 more source

Megaloblastic anaemia during methotrexate treatment of psoriasis. [PDF]

, 1966
Peter Borrie, Peter A. Clark
openalex   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency

British Journal of Clinical Pharmacology, EarlyView.
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Siyu Wu, Lee Mozessohn, Richard B. Kim, Jonathan S. Zipursky   +3 more
wiley   +1 more source