Results 131 to 140 of about 369,868 (397)

Biologic therapy with anti-TNFa in rheumathoid atrhritis

Reumatismo, 2011
Objective: To evaluate the efficacy, the tolerability, and treatment survival of the association of anti-TNFa (Infliximab, Etanercept, Adalimumab) plus Methotrexate vs Methotrexate as monotherapy in patients with reumathoid arthritis (RA).
G. Ferraccioli
doaj   +1 more source

Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature [PDF]

, 2020
Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis.
Cartron, Alexander M, Chung, Catherine, Osler, Montana, Trinidad, John C   +3 more
core  

Golimumab, a human anti–tumor necrosis factor α monoclonal antibody, injected subcutaneously every four weeks in methotrexate‐naive patients with active rheumatoid arthritis: Twenty‐four–week results of a phase III, multicenter, randomized, double‐blind, placebo‐controlled study of golimumab before methotrexate as first‐line therapy for early‐onset rheumatoid arthritis [PDF]

, 2009
Paul Emery, Roy Fleischmann, Larry W. Moreland, Elizabeth C. Hsia, Ingrid Strusberg, Patrick Durez, Peter Nash, Eric Amante, Melvin Churchill, Won Park, Bernardo A. Pons‐Estel, Mittie K. Doyle, Sudha Visvanathan, Weichun Xu, Mahboob U. Rahman   +14 more
openalex   +1 more source

Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia

OncoTarget, 2017
High-dose methotrexate (HDMTX) plays an important role in the treatment of acute lymphoblastic leukemia (ALL) although there is great inter-patient variability in the efficacy and toxicity of MTX.
Shuguang Liu, Chao Gao, Rui-dong Zhang, Xiaoxi Zhao, L. Cui, Weijing Li, Zhen-Ping Chen, Zhixia Yue, Yuan-Yuan Zhang, Min-Yuan Wu, Jian-Xiang Wang, Zhigang Li, Huyong Zheng   +12 more
semanticscholar   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

Phase II Study of ABT‐122, a Tumor Necrosis Factor– and Interleukin‐17A–Targeted Dual Variable Domain Immunoglobulin, in Patients With Psoriatic Arthritis With an Inadequate Response to Methotrexate [PDF]

, 2018
Philip J. Mease, Mark C. Genovese, Michael E. Weinblatt, Paul M. Peloso, Kun Chen, Mohamed I. A. Othman, Yihan Li, Heikki Mansikka, Amit Khatri, Neil Wishart, John Liu   +10 more
openalex   +1 more source

Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study

Arthritis & Rheumatology, 2015
To evaluate the efficacy and safety of sarilumab in combination with methotrexate (MTX) for the treatment of rheumatoid arthritis (RA).
M. Genovese, R. Fleischmann, A. Kivitz, M. Rell-Bakalarska, R. Martinčová, S. Fiore, P. Rohane, H. van Hoogstraten, A. Garg, C. Fan, J. van Adelsberg, S. Weinstein, N. Graham, N. Stahl, G. Yancopoulos, T. Huizinga, D. M. van der Heijde   +16 more
semanticscholar   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Predictors Associated with Delayed Methotrexate Clearance among Patients with Haematological Malignancies

Journal of Pharmacy
Introduction: High dose methotrexate is commonly utilised in haematological malignancies; however, the prevalence of delayed clearance is not well-defined.
Muhammad Nasri Yusoff, Noraida Mohamed Shah, Nor Asyikin Mohd Tahir, Sakina Nur Najah Abdul Jabar, Ahlam Naila Kori, Nor Rafeah Tumian   +5 more
doaj  

Single Dose Methotrexate in Treatment of Ectopic Pregnancy: Review of 32 Case

Balkan Medical Journal, 2011
Objective: To evaluate the efficacy of single dose intramuscular methotrexate in the treatment of ectopic pregnancy.Material and Methods: 32 patients who matched the inclusion criteria were enrolled.
Aysun Aybatlı, Petek Balkanlı Kaplan, Mehmet Alicik, Niyazi Cenk Sayın, Mehmet Ali Yüce   +4 more
doaj