Results 121 to 130 of about 917,353 (421)

Oxidation of Methyl (Methylthio)methyl Sulfoxide [PDF]

Bulletin of the Chemical Society of Japan, 1980
Abstract Oxidation of methyl (methylthio)methyl sulfoxide (2) with hydrogen peroxide in acetic acid or methanol produced bis(methylsulfinyl)methane in high yield. Similar results were obtained in oxidation of 2 with ozone, sodium metaperiodate, and m-chloroperbenzoic acid.
Gen-ichi Tsuchihashi, Michiyo Suzuki, Katsuyuki Ogura   +2 more
openaire   +3 more sources

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Nature Cell Biology, 2018
N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer.
J. Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu, Kangkang Yu, Samantha M. Tienda, Agnieszka Chryplewicz, Allen C. Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhigao Xu, X. Leng, Xue Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, E. Lengyel, Chuan He   +19 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations

HGG Advances, 2022
Summary: Copy-number variations (CNV) are believed to play an important role in a wide range of complex traits, but discovering such associations remains challenging.
Maarja Lepamets, Chiara Auwerx, Margit Nõukas, Annique Claringbould, Eleonora Porcu, Mart Kals, Tuuli Jürgenson, Andrew Paul Morris, Urmo Võsa, Murielle Bochud, Silvia Stringhini, Cisca Wijmenga, Lude Franke, Hedi Peterson, Jaak Vilo, Kaido Lepik, Reedik Mägi, Zoltán Kutalik   +17 more
doaj  

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Methyl bromide and methyl chloride in the Southern Ocean [PDF]

Journal of Geophysical Research: Oceans, 2004
Air and water concentrations of methyl bromide (CH3Br) and methyl chloride (CH3Cl) were measured in the Southern Ocean (latitudes 45°–67°S, longitudes 144°–139°E) from late October through mid‐December 2001. CH3Br and CH3Cl were undersaturated with mean saturation anomalies of −39 ± 11% and −37 ± 11% between 45° and 65°S.
James H. Butler, Kelly D. Goodwin, Kelly D. Goodwin, Eric S. Saltzman, Ryszard Tokarczyk, Ryszard Tokarczyk, Daniel B. King, Daniel B. King, Daniel B. King, Shari A. Yvon-Lewis   +9 more
openaire   +4 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A subset of methylated CpG sites differentiate psoriatic from normal skin. [PDF]

, 2012
Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin compared with normal skin.
Bowcock, Anne M, Cao, Li, Duan, Shenghui, Joyce, Cailin E, Liao, Wilson, Liu, Ying, Martin, Ann, Menter, Alan, Roberson, Elisha DO, Ryan, Caitriona   +9 more
core   +1 more source

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Nature Communications, 2018
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions.
Stephen J. Clark, R. Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, G. Sanguinetti, G. Kelsey, J. Marioni, O. Stegle, W. Reik   +11 more
semanticscholar   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source