Results 121 to 130 of about 1,050,423 (388)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]

, 2018
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R., C., Squarcina, Carli, De, F., Brambilla, F., Sirgiovanni, Fumagalli, M., I., Giorda, L., Pozzoli, Montirosso, Rosario, Mosca, F., P., Dessimone, Provenzi, L., R., Cinnante, U., Triulzi   +13 more
core   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Infection with a Virulent Strain of Wolbachia Disrupts Genome Wide-Patterns of Cytosine Methylation in the Mosquito Aedes aegypti [PDF]

, 2015
BACKGROUND Cytosine methylation is one of several reversible epigenetic modifications of DNA that allow a greater flexibility in the relationship between genotype and phenotype.
Caragata, Eric P., Huttley, Gavin A., McGraw, Elizabeth A., O'Neill, Scott L., Popovici, Jean, Rancès, Edwige, Woolfit, Megan, Ye, Yixin H.   +7 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells

International Journal of Nanomedicine, 2020
Tianke Zhang,1,2 E Du,1 Yan Liu,1 Jun Cheng,2 Zhihong Zhang,1 Yong Xu,1 Shiyong Qi,1 Yue Chen1 1Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, People’s Republic of China ...
Zhang T, Du E, Liu Y, Cheng J, Zhang Z, Xu Y, Qi S, Chen Y   +7 more
doaj  

Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface [PDF]

, 2009
Plasma concentrations of biologically active vitamin D (1,25- (OH)2D) are tightly controlled via feedback regulation of renal 1-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.
Albertson, Anderson, Arai, Avila, Barrera, Barrera, Bock, Bodnar, Boris Novakovic, Carter, Chaddha, Chiu, Chung, Coan, d'Alesio, Danielle Evain-Brion, Davis, Deeb, DeLuca, Delvin, Delvin, Diaz, Dimitriadis, Dodds, Du, Dusso, Eva Dimitriadis, Evans, Evans, Fischer, Friso, Holick, Hong Kiat Ng, Jeffrey M. Craig, Jennings, Kim, Kohler, Kovacs, Kumar, Lauridsen, Leader, Lechner, Li, Liu, Lohnes, Lopez, Lopez, Makin, Malloy, Mandy Sibson, Masuda, Muller, Murayama, Nelen, Nelen, Nelen, Novakovic, Ohyama, Pattillo, Pattillo, Paulson, Pavan, Peehl, Pendas-Franco, Pospechova, Rahnama, Rakyan, Richard Saffery, Ron, Ross, Ross, Ruth Morley, Salle, Seely, Serman, Shih Ie, Sikora, Siu-Caldera, Soundararajan, Stephan Beck, Stephanou, Sung, Tapia, Tashiro, Taylor, Thierry Fournier, Thomas Down, Tsang, Ursula Manuelpillai, Valdivielso, van der Molen, Vardhman Rakyan, Vigano, von Rango, Whitfield, Wietrzyk, Wong, Wong, Xie, Zehnder, Zhang, Zhou   +101 more
core   +3 more sources

Magic methylation with methyl-containing peroxides

Chemical Science
Methyl groups are abundant in pharmaceuticals, and their installation has garnered significant attention. This review summarises advancements in the use of methyl-containing peroxides as reagents for a variety of methylation reactions.
Daliah Farajat, Yuhua Zhang, Chao-Jun Li
openaire   +2 more sources

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Nature Cell Biology, 2018
N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer.
J. Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu, Kangkang Yu, Samantha M. Tienda, Agnieszka Chryplewicz, Allen C. Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhigao Xu, X. Leng, Xue Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, E. Lengyel, Chuan He   +19 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source