Results 121 to 130 of about 1,069,555 (390)

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Nature Cell Biology, 2018
N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer.
J. Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu, Kangkang Yu, Samantha M. Tienda, Agnieszka Chryplewicz, Allen C. Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhigao Xu, X. Leng, Xue Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, E. Lengyel, Chuan He   +19 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

DNA Methylation Cancer Biomarkers: Translation to the Clinic

Frontiers in Genetics, 2019
Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with focal hypermethylation of numerous 5’-cytosine-phosphate-guanine-3’ (CpG) islands, often ...
Warwick J. Locke, Dominic Guanzon, Chenkai Ma, Y. Liew, Konsta Duesing, K. Fung, Jason Ross   +6 more
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. [PDF]

, 2016
Cytochrome P450 (CYP) 1A1 is a phase I enzyme that can activate various compounds into reactive forms and thus, may contribute to carcinogenesis. In this study, we investigated the expression, methylation status, and functional role of CYP1A1 on prostate
Chang, Inik, Dahiya, Rajvir, Deng, Guoren, Fukuhara, Shinichiro, Hashimoto, Yutaka, Imai-Sumida, Mitsuho, Kato, Taku, Majid, Shahana, Mitsui, Yozo, Nakajima, Koichi, Saini, Sharanjot, Shiina, Hiroaki, Shiina, Marisa, Tanaka, Yuichiro, Wong, Darryn K, Yamamura, Soichiro   +15 more
core   +1 more source

Carbon-13 n.m.r. investigation on the nitrogen methylation of the mono- and diazanaphthalenes [PDF]

, 1977
The 13C n.m.r. spectra of the N-methylated mono- and diazanaphthalenes have been recorded and analysed. It has been shown that N-methylation as well as N-protonation in cinnoline occur predominantly at the -nitrogen atom.
Ham, Dirk M.W. van den, Mohan, Chandra, Weijer, Peter van de   +2 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Infection with a Virulent Strain of Wolbachia Disrupts Genome Wide-Patterns of Cytosine Methylation in the Mosquito Aedes aegypti [PDF]

, 2015
BACKGROUND Cytosine methylation is one of several reversible epigenetic modifications of DNA that allow a greater flexibility in the relationship between genotype and phenotype.
Caragata, Eric P., Huttley, Gavin A., McGraw, Elizabeth A., O'Neill, Scott L., Popovici, Jean, Rancès, Edwige, Woolfit, Megan, Ye, Yixin H.   +7 more
core   +1 more source

DNA methylation analysis of WIF1 and DKK4 in cervical precancerous lesions and cancer

Journal of Education, Health and Sport, 2019
Epigenetic gene silencing by excessive methylation was found in many tumors. Methylation of tumor suppressor genes is often found in cervical cancer, which is an important pathogenetic factor of oncologic process.
I. Gladchuk, N. Rozhkovska, N. Kashtalian, A. Volyanska, G. Lavrynenko   +4 more
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