Results 101 to 110 of about 607,486 (297)

Decoding epigenetic markers: implications of traits and genes through DNA methylation in resilience and susceptibility to mastitis in dairy cows

Epigenetics
Cattle farming faces challenges linked to intensive exploitation and climate change, requiring the reinforcement of animal resilience in response to these dynamic environments.
Lotfi Bouzeraa, Helene Martin, Clement Plessis, Pascal Dufour, Jessica C. S. Marques, Sydney Moore, Ronaldo Cerri, Marc-Andre Sirard   +7 more
doaj   +1 more source

Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression [PDF]

, 2014
Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-responsiveness to growth inhibitory signals. Both genetic and epigenetic changes
de Las Heras, Jose Ignacio, Xenophontos, Maria, Stancheva, Irina, Bao, Xun X., Clouaire, Thomas, Kemp, Sadie E., Gordon, Katrina   +6 more
core   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

BDNF gene methylation in brain of suicide subjects [PDF]

, 2009
: Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology of suicidal behaviour and BDNF levels are decreased in brain and plasma of suicide subjects.
Keller, Simona
core   +1 more source

Prediction of NR3C1 as a methylation marker for the prevention and treatment of gastric cancer in Rhizoma Atractylodis Macrocephalae based on machine learning algorithm and bioinformatics analysis

Frontiers in Genetics
ObjectiveThe aim of this study was to identify the markers of Rhizoma Atractylodis Macrocephalae (RAM) for the prevention and treatment of gastric cancer using bioinformatics analysis.MethodsThe main active components of RAM were screened using the ...
Shicong Huang, Qian Gu, Yan Chen, Xiaofang Huang, Yuhua Du, Ziying Zhou, Yi Nan, Ling Yuan   +7 more
doaj   +1 more source

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus [PDF]

, 2010
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality.
Bell Christopher G, Savage, DA, Savage, David A., Savage, D.A., Bell, CG, Beck, Stephan, Stephan Beck, Maxwell, Alexander P.; id_orcid, Maxwell, Alexander P., Maxwell, A.P., Teschendorff, AE, Beck Stephan, Rakyan, VK, Rakyan, V.K., David A Savage, Teschendorff, Andrew E., Christopher G Bell, Andrew E Teschendorff, Maxwell Alexander P, Alexander P Maxwell, Bell, Christopher G., Rakyan, Vardhman K., Savage David A, Beck, S, Rakyan Vardhman K, Bell, C.G., Beck, S., Maxwell, AP, Teschendorff, A.E., Vardhman K Rakyan, Teschendorff Andrew E   +30 more
core   +1 more source

Correlation between MGMT methylation and the efficacy of bevacizumab in high-grade glioma

Frontiers in Oncology
PurposeThe aim of this study is to investigate whether the therapeutic efficacy of bevacizumab (BEV) in the treatment of high-grade glioma (HGG) is associated with the methylation status of O6-methylguanine-DNA methyltransferase (MGMT) on the basis of ...
Chengrui Yan, Xuexue Bai, Chao Wu, Wenbin Ma, Ming Feng   +4 more
doaj   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Multidimensional roles of cfDNA fragmentomics in preeclampsia: from placental hypoxia and TLR9 inflammation to clinical risk stratification

Frontiers in Medicine
Cell-free DNA (cfDNA) has emerged as a pivotal biomarker for predicting preeclampsia (PE), a multisystem syndrome characterized by placental hypoperfusion and systemic inflammation.
Ziyi Guo, Bin Zhang, Di Yang, Li Wang
doaj   +1 more source