Results 81 to 90 of about 607,486 (297)
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Epigenetic modelling: DNA methylation and working towards model parameterisation [PDF]
, 2011 The main focus of the research in this thesis is the investigation in DNA methylation mechanisms of epigenetics and the study of a specific database. As part of the latter work, the role of curation is described, and a new knowledge management system ...
Porwal, Jyoti
core +2 more sources
, 2017 Objective: Signal transducer and activator of transcription (STAT) 1 is a key tumor suppressor, which is always methylated in a variety of human cancers.
Chang, Ming-Cheng;Chiang, Ying-Cheng;Ho, Chih-Ming;Chen, Yu-Li;Chen, Chi-An;Cheng, Wen-Fang;Chou, Cheng-Yang +1 more
core +1 more source
DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]
, 2014 Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B. +8 more
core +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
The Methylation of Nicotine with Methyl-lithium. [PDF]
Acta Chemica Scandinavica, 1967 F. Haglid +8 more
openaire +2 more sources
Psychosocial stress experience and DNA methylation in humans - implications for stress-adaptation and -resilience [PDF]
, 2014 : Background: Psychosocial stress, especially early in life, is a risk factor for mental disorders. Recent evidence suggests that stress-related changes in epigenetic patterns, including DNA methylation, could mediate this association. Aim: to examine a
Unternaehrer, Eva
core +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Современная ревматологияOsteoporosis (OP) is a common disease leading to low-trauma fractures and is a serious medical and social problem. Often a fracture is the first clinical manifestation of OP that has been asymptomatic for a long time, necessitating the development of ...
A. V. Tyurin +4 more
doaj +1 more source