Results 61 to 70 of about 557,393 (318)

Methylation of DNA [PDF]

The Journal of General Physiology, 1966
The methylated bases of DNA are formed by the transfer of the methyl group from S-adenosylmethionine to a polynucleotide acceptor. This transfer is catalyzed by highly specific enzymes which recognize a limited number of available sites in the DNA. The mechanism for the recognition is presently unknown.
M, Gold, M, Gefter, R, Hausmann, J, Hurwitz   +3 more
openaire   +2 more sources

Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis [PDF]

, 2011
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is similar to 50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease.
Busato, F, Manfras, B, Kerith-rae M, Leslie, R. David, Jörg Tost, Manfras Burkhard, Mohammed I Hawa, Thomas A. Down, Maslau, S, Leslie, RD, Mohammed I. Hawa, Bernhard O Boehm, Beck Stephan, Rakyan, VK, Aden Deeqo, Daunay, A, Maslau Siarhei, Down Thomas A., Dias, Kerith-Rae M., Bell, Christopher G., Rakyan, Vardhman K., Boehm, Bernhard O., Beck, S, Bell Christopher G., Leslie R. David, Charles A. Mein, Charles A Mein, Boehm Bernhard O., Vardhman K Rakyan, Beyan, H, Burkhard Manfras, Christopher G. Bell, Hawa, MI, Kerith-Rae M. Dias, Vardhman K. Rakyan, R David Leslie, Kerith-Rae M Dias, Siarhei Maslau, Hawa Mohammed I., Busato Florence, Deeqo Aden, Bell, CG, Beck, Stephan, Stephan Beck, Bernhard O. Boehm, Busato, Florence, Dias Kerith-Rae M., Tost Jörg, Mein, Charles A., Christopher G Bell, Dias, KRM, Tost, J, Maslau, Siarhei, Hawa, Mohammed I., Daunay, Antoine, R. David Leslie, Florence Busato, Down, Thomas A., Rakyan Vardhman K., Tost, Jörg, Mein, CA, Daunay Antoine, Beyan, Huriya, Down, TA, Boehm, BO, Huriya Beyan, Antoine Daunay, Mein Charles A., Manfras, Burkhard, Thomas A Down, Beyan Huriya, Aden, D, Aden, Deeqo   +72 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Epigenetic modelling: DNA methylation and working towards model parameterisation [PDF]

, 2011
The main focus of the research in this thesis is the investigation in DNA methylation mechanisms of epigenetics and the study of a specific database. As part of the latter work, the role of curation is described, and a new knowledge management system ...
Porwal, Jyoti
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Histone modifications in head and neck squamous cell carcinoma

Frontiers in Oncology
Head and neck cancer is the main cause of cancer death worldwide, with squamous cell carcinoma (HNSCC) being the second most frequent subtype. HNSCC poses significant health threats due to its high incidence and poor prognosis, underscoring the urgent ...
Wei Mao, Baoxin Wang, Ruofei Huang, Zhenfeng Sun, Minzhu Yan, Pin Dong   +5 more
doaj   +1 more source

Methyl eucomate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: methyl 3-carboxy-3-hydr-oxy-3-(4-hydroxy-benz-yl)propanoate], C(12)H(14)O(6), is stabilized by inter-molecular O-H⋯O and C-H⋯O hydrogen bonds. The mol-ecules are arranged in layers, parallel to (001), which are inter-connected by the O-H⋯O hydrogen bonds.
Linglin Li, Guang-Xiong Zhou, Ren-Wang Jiang   +2 more
openaire   +3 more sources

New primers for methylation-specific polymerase chain reaction enhance specificity of detecting STAT1 methylation

, 2017
Objective: Signal transducer and activator of transcription (STAT) 1 is a key tumor suppressor, which is always methylated in a variety of human cancers.
Chang, Ming-Cheng;Chiang, Ying-Cheng;Ho, Chih-Ming;Chen, Yu-Li;Chen, Chi-An;Cheng, Wen-Fang;Chou, Cheng-Yang, 鄭文芳;陳祈安;江盈澄   +1 more
core   +1 more source

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus [PDF]

, 2010
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality.
Bell Christopher G, Savage, DA, Savage, David A., Savage, D.A., Bell, CG, Beck, Stephan, Stephan Beck, Maxwell, Alexander P.; id_orcid, Maxwell, Alexander P., Maxwell, A.P., Teschendorff, AE, Beck Stephan, Rakyan, VK, Rakyan, V.K., David A Savage, Teschendorff, Andrew E., Christopher G Bell, Andrew E Teschendorff, Maxwell Alexander P, Alexander P Maxwell, Bell, Christopher G., Rakyan, Vardhman K., Savage David A, Beck, S, Rakyan Vardhman K, Bell, C.G., Beck, S., Maxwell, AP, Teschendorff, A.E., Vardhman K Rakyan, Teschendorff Andrew E   +30 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source