Results 61 to 70 of about 795,435 (189)

Association of DNA Promoter Methylation and BRAF Mutation in Thyroid Cancer

Current Oncology, 2023
The BRAF V600E mutation and DNA promoter methylation play important roles in the pathogenesis of thyroid cancer (TC). However, the association of these genetic and epigenetic alterations is not clear.
Farzana Jasmine, Briseis Aschebrook-Kilfoy, Mohammad M. Rahman, Garrett Zaagman, Raymon H. Grogan, Mohammed Kamal, Habibul Ahsan, Muhammad G. Kibriya   +7 more
doaj   +1 more source

Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum [PDF]

, 2013
DNA cytosine methylation is a widely conserved epigenetic mark in eukaryotes that appears to have critical roles in the regulation of genome structure and transcription.
Ahmed, Ikhlak, Allen, Andrew, Bhavsar, Jaysheel, Bondurant, Sandra Splinter, Bowler, Chris, Creasy, Todd, Crom, Stéphane Le, Farrant, Gregory K., Lin, Xin, Maumus, Florian, O'Brien, Kimberly, Olson, Sue A., Rabinowicz, Pablo D., Rayko, Edda, Rivarola, Maximo Lisandro, Sengamalay, Naomi A., Sgro, Jean-Yves, Smith, Andrew D., Sussman, Michael R., Tallon, Luke J., Tirichine, Leïla, Veluchamy, Alaguraj   +21 more
core   +2 more sources

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Histone modifications in head and neck squamous cell carcinoma

Frontiers in Oncology
Head and neck cancer is the main cause of cancer death worldwide, with squamous cell carcinoma (HNSCC) being the second most frequent subtype. HNSCC poses significant health threats due to its high incidence and poor prognosis, underscoring the urgent ...
Wei Mao, Baoxin Wang, Ruofei Huang, Zhenfeng Sun, Minzhu Yan, Pin Dong   +5 more
doaj   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Andrews, TD, Beck, S, Berlin, K, Cox, AV, Fischer, J, Gut, IG, Hildmann, T, Howe, KL, Lewin, J, Novik, KL, Olek, A, Otto, T, Rakyan, VK, Tost, J   +13 more
core  

Molecular Analysis of N6-Methyladenine Patterns in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e Nuclear DNA [PDF]

, 1989
We have cloned two DNA fragments containing 5\u27-GATC-3\u27 sites at which the adenine is methylated in the macronucleus of the ciliate Tetrahymena thermophila. Using these cloned fragments as molecular probes, we analyzed the maintenance of methylation
Capowski, Elizabeth E., Harrison, Gail Singer, Karrer, Kathleen M., Wells, John M.   +3 more
core   +1 more source

Possible role of GADD45γ methylation in diffuse large B-cell Lymphoma: Does it affect the progression and tissue involvement? [PDF]

, 2015
Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among adults and is characterized by heterogeneous clinical, immunophenotypic, and genetic features.
Barış, İkbal Cansu, Bağcı, Gülseren, Can, Özge, Caner, Vildan, Doğu, Mehmet Hilmi, Hacıoğlu, Sibel, Keskin, Ali, Sarı, İsmail, Tepeli, Emre, Türk, Nilay Şen, Çetin, Ozan   +10 more
core   +2 more sources

Impact of Folic Acid on the Resistance of Non-small Cell Lung Cancer Cells 
to Osimertinib by Regulating Methylation of DUSP1

Chinese Journal of Lung Cancer, 2023
Background and objective Drug resistance is the main cause of high mortality of lung cancer. This study was conducted to investigate the effect of folic acid (FA) on the resistance of non-small cell lung cancer (NSCLC) cells to Osimertinib (OSM) by ...
Wenjuan HE, Li LIU
doaj   +1 more source

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma [PDF]

, 2016
Background: Cytology-based screening methods for cervical adenocarcinoma (ADC) and to a lesser extent squamous-cell carcinoma (SCC) suffer from low sensitivity.
Boers, Aniek, De Meyer, Tim, Klip, Harry G, Schuuring, Ed, Steenbergen, Renske DM, Van Criekinge, Wim, van der Zee, Ate GJ, van Leeuwen, Robert W, Wang, Rong, Wisman, G Bea A   +9 more
core   +2 more sources

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]

, 2017
INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya, Ding, Lili, Geisler, Kristie, Ji, Hong, Martin, Lisa J, Sadhasivam, Senthilkumar, Stubbeman, Bobbie L, Weirauch, Matthew T, Zhang, Xue   +8 more
core   +1 more source