Results 51 to 60 of about 607,486 (297)
Search for differentially methylated regions in ancient and modern genomes
Вавиловский журнал генетики и селекции, 2023 Currently, active research is focused on investigating the mechanisms that regulate the development of various pathologies and their evolutionary dynamics. Epigenetic mechanisms, such as DNA methylation, play a significant role in evolutionary processes,
D. D. Borodko +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Stability of Blood DNA Methylation Across Two Timepoints in Three Cohorts
BiomedicinesBackground: DNA methylation mediates the gene–environment interactions, with implications for health and disease. Studies with sampling at more than one timepoint revealed the considerable variability of the blood methylome, but comprehensive resources ...
Mikołaj Danielewski +3 more
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Association of DNA Promoter Methylation and BRAF Mutation in Thyroid Cancer
Current Oncology, 2023 The BRAF V600E mutation and DNA promoter methylation play important roles in the pathogenesis of thyroid cancer (TC). However, the association of these genetic and epigenetic alterations is not clear.
Farzana Jasmine +7 more
doaj +1 more source
Magic methylation with methyl-containing peroxides
Chemical ScienceMethyl groups are abundant in pharmaceuticals, and their installation has garnered significant attention. This review summarises advancements in the use of methyl-containing peroxides as reagents for a variety of methylation reactions.
Daliah Farajat, Yuhua Zhang, Chao-Jun Li
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Epigenetic Therapies in Melanoma—Targeting DNA Methylation and Histone Modification
BiomedicinesSkin cancer prevalence has increased during the last decades, with the last years serving as a pivotal moment for comprehending its epidemiological patterns and its impact on public health.
Adrian Bogdan Tigu +9 more
doaj +1 more source
The Toxicity of Methylal [PDF]
Occupational and Environmental Medicine, 1951 dimethoxymethane, formaldehyde dimethyl acetal and m?thyl?ne dimethyl ether, the simplest of the group of acet?is, can be prepared very simply by the interaction of formaldehyde and methanol catalyzed by dry hydrogen chloride or even by calcium chloride, ft is a clear, thin, mobile liquid, lighter than water, and soluble in water to the extent of one ...
F L, WEAVER +3 more
openaire +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source