Results 31 to 40 of about 607,486 (297)

The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients

Diagnostics, 2020
Acute myeloid leukemia (AML) is a hematologic malignancy characterized by abnormal proliferation and a lack of differentiation of myeloid blasts. Considering the dismal prognosis this disease presents, several efforts have been made to better classify it
Sergiu Pasca, Cristina Turcas, Ancuta Jurj, Patric Teodorescu, Sabina Iluta, Ionut Hotea, Anca Bojan, Cristina Selicean, Bogdan Fetica, Bobe Petrushev, Vlad Moisoiu, Alina-Andreea Zimta, Valentina Sas, Catalin Constantinescu, Mihnea Zdrenghea, Delia Dima, Ciprian Tomuleasa   +16 more
doaj   +1 more source

DNA methylation patterns in cord blood DNA and body size in childhood. [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND ...
Pearce, M., Mark S. Pearce (177539), Ness, Andy R, Caroline L Relton, St Pourcain, B., Joseph Trakalo (177545), Shaheen Seif O., Embleton, N., Swan, DC, Ness, AR, George Davey Smith (82619), Seif O. Shaheen (177559), Shaheen, S., Relton, Caroline L, Ring, SM, Relton, C., Jon H Tobias, Swan, D., Sayers, AE, Alexandra Groom, Caroline L. Relton (174120), Susan M. Ring (116089), Embleton Nicholas D., Alexandra Groom (174101), Andy R Ness, Andy R. Ness (177551), Ring Susan M., Beate St. Pourcain (152905), Sayers, Adrian E, Tobias Jon H., Ness Andy R., Trakalo, J, St Pourcain, B, Sayers Adrian E., Groom, A., Tobias, Jonathan H, Relton Caroline L., St. Pourcain Beate, St Pourcain, M U B, Nicholas D Embleton, Tobias, J., Jon H. Tobias (153172), Northstone, K., Beate St Pourcain, Northstone, K, Davey Smith George, Trakalo Joseph, Groom Alexandra, Joseph Trakalo, Sayers, A., Kate Northstone (74777), Tobias, JH, Davey Smith, George, Groom, A, Ring, Susan M, Davey Smith, G, Pearce, MS, Northstone, Kate, Nicholas D. Embleton (177535), Susan M Ring, Pearce Mark S., Daniel C Swan, Ness, A., Swan Daniel C., Mark S Pearce, Northstone Kate, Relton, CL, Adrian E Sayers, Shaheen, SO, George Davey Smith, Trakalo, J., Adrian E. Sayers (177532), Embleton, ND, Davey Smith, G., Kate Northstone, Seif O Shaheen, Ring, S., Daniel C. Swan (124594)   +77 more
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Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review

Oncology Reviews
SLC25A26 is the only known human mitochondrial S-adenosylmethionine carrier encoding gene. Recent studies have shown that SLC25A26 is abnormally expressed in some cancers, such as cervical cancer, low-grade glioma, non-small cell lung cancer, and liver ...
Yangheng Xu, Zhisheng Hong, Sheng Yu, Ronghan Huang, Kunqi Li, Ming Li, Sisi Xie, Lvyun Zhu   +7 more
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Global Methylation and Protamine Deficiency in Ram Spermatozoa Correlate with Sperm Production and Quality but Are Not Influenced by Melatonin or Season

Animals, 2020
This study assessed whether the seasonal effects of melatonin that upregulate ram reproductive function alter sperm global methylation or protamine deficiency and whether these parameters corresponded to ram endocrinology, semen production and quality ...
Kelsey R. Pool, Jessica P. Rickard, Simon P. de Graaf   +2 more
doaj   +1 more source

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican   +18 more
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Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma

Gut and Liver, 2008
Background/Aims: RUNX3 (PEBP2ՁC/CBFA3/AML2) is a novel tumor suppressor gene in the human gastric carcinoma. The aims of this study were to determine the methylation of RUNX3 promoter and the association between RUNX3 methylation and the ...
doaj   +1 more source

Aberrant DNA methylation of PTPRG as one possible mechanism of its under‐expression in CML patients in the State of Qatar

Molecular Genetics & Genomic Medicine, 2020
Background Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated in chronic myeloid ...
Mohamed A. Ismail, Muthanna Samara, Ali Al Sayab, Mohamed Alsharshani, Mohamed A. Yassin, Govindarajulu Varadharaj, Marzia Vezzalini, Luisa Tomasello, Maria Monne, Hisham Morsi, M. Walid Qoronfleh, Hatem Zayed, Richard Cook, Claudio Sorio, Helmout Modjtahedi, Nader I. Al‐Dewik   +15 more
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Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation

Current Issues in Molecular Biology
Tissue regeneration therapy based on human dental pulp cells (hDPCs) faces the distinct challenge of cellular senescence during massive expansion in vitro.
Shuhan Zhou, Jingyao Cui, Yu Shi
doaj   +1 more source

Methylation characteristics and clinical significance of glutathione peroxidase 3 in malignant pleomorphic adenoma

Kouqiang hemian waike zazhi
[Objective:] To observe the methylation and protein levels of glutathione peroxidase 3 (GPX3) in malignant pleomorphic adenoma (MPA) tissue and its clinical significance.
LIU Xiao, SUN Jiangwei, ZHOU Jing
doaj   +1 more source

Analysis of tissue-specific & allele-specific DNA methylation [PDF]

, 2010
Epigenetic mechanisms such as histone modifications and DNA methylation extend the information of the underlying genomic DNA sequence. Understanding cell type-specific epigenetic codes on a global level is a major challenge after the sequencing of the ...
Schilling, Elmar
core   +1 more source