Results 31 to 40 of about 426,231 (268)

Global Methylation and Protamine Deficiency in Ram Spermatozoa Correlate with Sperm Production and Quality but Are Not Influenced by Melatonin or Season

Animals, 2020
This study assessed whether the seasonal effects of melatonin that upregulate ram reproductive function alter sperm global methylation or protamine deficiency and whether these parameters corresponded to ram endocrinology, semen production and quality ...
Kelsey R. Pool, Jessica P. Rickard, Simon P. de Graaf   +2 more
doaj   +1 more source

Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma

Gut and Liver, 2008
Background/Aims: RUNX3 (PEBP2ՁC/CBFA3/AML2) is a novel tumor suppressor gene in the human gastric carcinoma. The aims of this study were to determine the methylation of RUNX3 promoter and the association between RUNX3 methylation and the ...
doaj   +1 more source

Aberrant DNA methylation of PTPRG as one possible mechanism of its under‐expression in CML patients in the State of Qatar

Molecular Genetics & Genomic Medicine, 2020
Background Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated in chronic myeloid ...
Mohamed A. Ismail, Muthanna Samara, Ali Al Sayab, Mohamed Alsharshani, Mohamed A. Yassin, Govindarajulu Varadharaj, Marzia Vezzalini, Luisa Tomasello, Maria Monne, Hisham Morsi, M. Walid Qoronfleh, Hatem Zayed, Richard Cook, Claudio Sorio, Helmout Modjtahedi, Nader I. Al‐Dewik   +15 more
doaj   +1 more source

Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation

Current Issues in Molecular Biology
Tissue regeneration therapy based on human dental pulp cells (hDPCs) faces the distinct challenge of cellular senescence during massive expansion in vitro.
Shuhan Zhou, Jingyao Cui, Yu Shi
doaj   +1 more source

Methylation characteristics and clinical significance of glutathione peroxidase 3 in malignant pleomorphic adenoma

Kouqiang hemian waike zazhi
[Objective:] To observe the methylation and protein levels of glutathione peroxidase 3 (GPX3) in malignant pleomorphic adenoma (MPA) tissue and its clinical significance.
LIU Xiao, SUN Jiangwei, ZHOU Jing
doaj   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Time to Diagnosis Among Children and Adolescents With Cancer in Québec, Canada: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen, Ronald D. Barr, Erin Strumpf, Mariam El‐Zein, Eduardo L. Franco, Talía Malagón   +5 more
wiley   +1 more source

Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5

Frontiers in Oncology
BackgroundLaryngeal cancer is a common head and neck cancer, and its occurrence and development are closely related to a variety of epigenetic modifications.
Linlu Li, Jiao Cui, Xiaoyu Li, Yuting Zhu, Hongfei Wu, Lanzhu Zhou   +5 more
doaj   +1 more source

Complementarity between miRNA expression analysis and DNA methylation analysis in hrHPV-positive cervical scrapes for the detection of cervical disease

Epigenetics, 2019
Cervical screening by high-risk HPV (hrHPV) testing requires additional risk stratification (triage), as most infections are transient and only a subset of hrHPV-positive women harbours clinically relevant disease.
Iris Babion, Lise M.A. De Strooper, Roosmarijn Luttmer, Maaike C.G. Bleeker, Chris J.L.M. Meijer, Daniëlle A.M. Heideman, Saskia M. Wilting, Renske D.M. Steenbergen   +7 more
doaj   +1 more source

CG Methylation [PDF]

Epigenomics, 2012
A striking feature of mammalian genomes is the paucity of the CG dinucleotide. There are approximately 20,000 regions termed CpG islands where CGs cluster. This represents 5% of all CGs and 1% of the genome. CpG islands are typically unmethylated and are often promoters for housekeeping genes.
Charles, Vinson, Raghunath, Chatterjee
openaire   +2 more sources