Results 11 to 20 of about 607,486 (297)

Clinical Impact of MGMT Promoter Methylation in IDH-Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding. [PDF]

Ann Clin Transl Neurol
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Jiang H, Cao L, Chen X, Tong S, Zhu Q, Yang J, Lin S, Cui Y.   +7 more
europepmc   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant-state stabilization. [PDF]

Mol Oncol
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
Kwon SH, Lee JM.
europepmc   +2 more sources

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Dominguez Salas, Paula, Dominguez-Salas, P, Prentice, AM, Sophie E. Moore, Cox, SE, Dominguez-Salas, Paula, Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Andrew M. Prentice, Moore, SE, Moore, Sophie E, Hennig, BJ, Cox, Sharon E, Prentice, Andrew M., Moore, Sophie E., Hennig, Branwen J., Branwen J. Hennig, Sharon E. Cox, Cox, Sharon E.   +19 more
core   +5 more sources

DNA methylation in follicular lymphoma [PDF]

, 2010
PhDFollicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival.
Ó Riain, Ciarán Liam
core   +4 more sources

Computational analysis of CpG site DNA methylation [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Epigenetics is the study of factors that can change DNA and passed to next generation without change to DNA sequence.
Ghorbani, Mohammadmersad
core   +7 more sources

From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia [PDF]

Epigenetics, 2009
The role of methylation in the history of psychiatry has traversed a storied path. The original trans-methylation hypothesis was proposed at a time when chlorpromazine had been synthesized but not yet marketed as an antipsychotic (Thorazine).
Dennis R, Grayson, Ying, Chen, Erbo, Dong, Marija, Kundakovic, Alessandro, Guidotti   +4 more
openaire   +2 more sources

Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche

Epigenetics, 2023
Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome ...
Diana Ponce, Fernando Rodríguez, José P. Miranda, Alexandra M. Binder, José L. Santos, Karin B. Michels, Gordon B. Cutler, Ana Pereira, Germán Iñiguez, Verónica Mericq   +9 more
doaj   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira, Hair, Alan, Miklos Gaszner, West Adam G., Gary Felsenfeld, Jacqueline Dickson, Dickson Jacqueline, Strogantsev, Ruslan, Gaszner Miklos, Dickson, Jacqueline, Adam G West, Humaira Gowher, Gaszner, Miklos, West, Adam G, Gowher, Humaira, West, Adam G., Felsenfeld Gary, Ruslan Strogantsev, Strogantsev Ruslan, Hair Alan, Felsenfeld, Gary, Alan Hair   +21 more
core   +2 more sources

Exercise effects on DNA methylation in EVL, CDKN2A (p14, ARF), and ESR1 in colon tissue from healthy men and women

Epigenetics, 2022
Physical activity reduces risk of colon cancer by 20–30%. Aberrant methylation patterns are common epigenetic alterations in colorectal adenomas, and cancers and play a role in cancer initiation and progression.
Catherine Duggan, Ming Yu, Amber R. Willbanks, Jean de Dieu Tapsoba, Ching-Yun Wang, William M. Grady, Anne McTiernan   +6 more
doaj   +1 more source

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source