Results 151 to 160 of about 1,069,555 (390)

Regulatory link between DNA methylation and active demethylation in Arabidopsis [PDF]

open access: bronze, 2015
Mingguang Lei   +5 more
openalex   +1 more source

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

open access: yesTranslational Psychiatry, 2019
Differential DNA methylation in the brain is associated with many psychiatric diseases, but access to brain tissues is essentially limited to postmortem samples. The use of surrogate tissues has become common in identifying methylation changes associated
Patricia R. Braun   +12 more
semanticscholar   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

open access: yesAdvanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen   +5 more
wiley   +1 more source

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

open access: yeseLife, 2019
CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy.
Xiao-Chuan Cai   +34 more
doaj   +1 more source

Role of Crosslinking and Backbone Segmental Dynamics on Ion Transport in Hydrated Anion‐Conducting Polyelectrolytes

open access: yesAdvanced Functional Materials, EarlyView.
Thermally crosslinked poly(2‐vinylpyridine)‐based anion conducting polyelectrolytes have been synthesized. The segmental dynamics of these polyelectrolytes have been systematically modified by varying the degree of crosslinking. Both the experimental and simulation results indicate that segmental dynamics have a limited influence on ion transport in ...
Zhongyang Wang   +11 more
wiley   +1 more source

Effective Sliding Motions of Vibration‐Induced Emission Stoppers in Mechanically Interlocked Molecules as Artificial Muscle Tougheners and In Situ Molecular Shuttling Sensors for Self‐Healable Mechano‐Fluorescent Polyurethane Organogels

open access: yesAdvanced Functional Materials, EarlyView.
The self‐healable ratiometric mechano‐fluorescent polyurethane (PU) organogel is constructed by incorporating a minor amount (ca. 1.5 wt.%) of the unconventional daisy chain rotaxane (as an artificial molecular muscle toughener) with specific sliding motions and ratiometric emission behaviors into the PU skeleton, which reveals the progressed intrinsic
Tu Thi Kim Cuc   +7 more
wiley   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans   +11 more
wiley   +1 more source

Effects of SCFA on the DNA methylation pattern of adiponectin and resistin in high-fat-diet-induced obese male mice [PDF]

open access: bronze, 2018
Yuanyuan Lu   +6 more
openalex   +1 more source

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