Results 151 to 160 of about 1,050,423 (388)
Revista Brasileira de Hematologia e Hemoterapia, 2009 Alterations in the methylation status of genes may contribute to the progression of Chronic Myeloid Leukemia (CML). In this study, the methylation status in exon2 of SOCS- 1 and promoter regions of both SOCS- 1 and JUNB were evaluated in CML patients ...
Márcia Cristina R. Pena +3 more
doaj
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Clinical Interventions in Aging, 2019 Tomohiro Kamo,1 Satoshi Kurose,1 Hiroshi Ohno,2 Minoru Murata,2 Masaki Hashiyada,3 Takanori Saito,2 Yutaka Kimura11Department of Health Science, Kansai Medical University, Osaka, Japan; 2Department of Orthopaedic Surgery, Kansai Medical University ...
Kamo T +6 more
doaj
On the Biological Methylation of Histamine. 4. [PDF]
, 1959 Kerstin M. Lindahl +5 more
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Role of TET enzymes in DNA methylation, development, and cancer
Genes & Development, 2016 Ten eleven translocation (TET) genes, and especially TET2, are frequently mutated in various cancers, but how the TET proteins contribute to the onset and maintenance of these malignancies is largely unknown. In this review, Rasmussen and Helin highlight
K. D. Rasmussen, K. Helin
semanticscholar +1 more source
Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium
FEBS Open Bio, EarlyView.By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita +3 more
wiley +1 more source
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion
eLife, 2019 CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy.
Xiao-Chuan Cai +34 more
doaj +1 more source
Chemistry of tissues. 4. Methylation studies on hyaluronic acid [PDF]
, 1951 Michael Kaye, M. Stacey
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, 2023 DNA methylation, one of the most studied epigenetic modifications, refers to the addition of a methyl group to the fifth carbon of cytosine (C) catalyzed by DNA methyltransferases(Dnmts), forming 5-methylcytosine (5mC). DNA methylation predominantly occurs inCpGs but is also found in non-CpG contexts.
openaire +1 more source
DNA Methylation Cancer Biomarkers: Translation to the Clinic
Frontiers in Genetics, 2019 Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with focal hypermethylation of numerous 5’-cytosine-phosphate-guanine-3’ (CpG) islands, often ...
Warwick J. Locke +6 more
semanticscholar +1 more source