Results 161 to 170 of about 2,934,821 (333)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Association betweenGSTPl gene promoter methylation and prostate cancer
Zhongguo aizheng zazhi, 2017 Background and purpose: Glutathione S-transferase P1 (GSTP1) protects cells from DNA damage and cancer cell formation. Inhibition of GSTP1 activity could increase susceptibility to DNA damage and increase the risk of cancer occurrence, which was ...
邢红宇, 朱明月
doaj
Advanced Science, EarlyView.ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu +20 more
wiley +1 more source
, 2016 DNA damage response (DDR) signaling network is initiated to protect cells from various exogenous and endogenous damage resources. Timely and accurate regulation of DDR proteins is required for distinct DNA damage repair pathways.
Wei-Guo Zhu +3 more
core +1 more source
Advanced Science, EarlyView.NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song +12 more
wiley +1 more source
Epigenetic dynamics of Helicobacter pylori-induced COX-2 activation
, 2009 Background and Aims: Cyclooxigenase (COX)-2 is over expressed in gastrointestinal neoplasia and Helicobacter pylori (H. pylori) infection is casually linked to gastric cancer. We undertook this study to investigate the mechanism mediating H.
Peluso, Silvia
core
Mechanisms of resistance to DNA methylation damage in human cells [PDF]
, 1997 Methylating agents such as N-methyl-N-nitrosourea (MNU) kill cells by introducing-O6-methylguanine (06-meGua) into DNA. Cells may avoid its cytotoxic effects by at least two mechanisms: increasing cellular levels of O6-methylguanine DNA methyltransferase
Hampson, Richard John
core
Advanced Science, EarlyView.This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin +12 more
wiley +1 more source
Dinâmica da metilação global do DNA e de poliaminas livres durante a indução e o desenvolvimento inicial de culturas nodulares de Vriesea reitzii Leme & A. Costa [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Recursos Genéticos Vegetais, Florianópolis, 2014.Vriesea reitzii Leme & Costa é uma bromélia da Floresta Atlântica, ocorre em ...
Vieira, Pâmela Martins
core
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source