Quantification of Methylisothiazolinone and Methylchloroisothiazolinone Preservatives by High-Performance Liquid Chromatography [PDF]
Isothiazolinone preservatives (methylisothiazolinone (MIT) and methylchloroisothiazolinone (CMIT) are commonly used in cosmetics, industrial and household products. However, these isothiazolinone derivatives are known to cause allergic contact dermatitis.
Samyah Alanazi +8 more
doaj +3 more sources
Methylchloroisothiazolinone and Methylisothiazolinone 10 Years After Regulation: A Case Story of Liquid Soaps and Shampoos. [PDF]
MCI/MI and MI contact allergy remain persistent. In this analysis of the Danish market, 257 products containing MCI/MI or MI were identified, and 30 products were analysed. Two exceeded regulatory limits, while most complied, suggesting current limits may require further investigation. Created in BioRender. Pedersen, M. K.
Pedersen MK +9 more
europepmc +2 more sources
An Unexpected Culprit: Allergic Contact Dermatitis Caused by Benzyl Alcohol in Moist Toilet Paper. [PDF]
Contact Dermatitis, Volume 95, Issue 1, Page 113-115, July 2026.
Rozas LM +3 more
europepmc +2 more sources
Prevalence of Contact Allergy to Isothiazolinones in Dermatitis Patients From 2000 to 2025: A Systematic Review and Meta-Analysis. [PDF]
ABSTRACT Isothiazolinones are employed in the preservation of cosmetic, consumer and industrial products, with the objective of preventing deterioration and spoilage. However, the utilization of isothiazolinones is associated with an elevated risk of developing contact allergy (CA).
Isufi D +6 more
europepmc +2 more sources
Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC). [PDF]
This study has shown a moderate performance of the regression model to predict current relevance (AUC = 0.679), although modelling performance has been better for specific allergens (e.g., nickel with an AUC = 0.770). Furthermore, it has identified key predictors, including female gender, specific involved sites (hands, neck, head, legs, feet), and ...
Pesqué D +31 more
europepmc +2 more sources
Prevalence of Contact Sensitisation Among Patients With Atopic Dermatitis in Thailand: A 20-Year Retrospective Study. [PDF]
Contact Dermatitis, Volume 94, Issue 6, Page 689-693, June 2026.
Kanokrungsee S +6 more
europepmc +2 more sources
Contact Sensitisation Trends in Slovenian Children and Adolescents: A Retrospective Single-Centre Study. [PDF]
Nickel sensitisation in children decreased significantly over time, while dyes and isothiazolinones are emerging allergens. These findings underscore shifting exposure patterns and the need for continuous surveillance to guide effective patch testing and prevention strategies.
Zorko MS, Lunder T, Peric T.
europepmc +2 more sources
Contact Sensitization in Adults With Atopic Dermatitis: A 21-Year Single-Center Tertiary Experience. [PDF]
A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Caroppo F +5 more
europepmc +2 more sources
Solid Shampoo Is Mostly Not Preserved, in Contrast to Liquid Shampoos Used in Hairdressing-A Market Survey in Four European Countries. [PDF]
Most solid shampoos (68.6%) did not contain preservatives according to Annex V of the EU Cosmetics Regulation (EC 1223/2009), while all liquid shampoos did. The number of preservatives used was significantly greater in liquid shampoos. ABSTRACT Background Hairdressers are frequently exposed to shampoos, both from neat liquid products and dilutions ...
Uter W +7 more
europepmc +2 more sources
Patch Testing in Individuals With Diabetes Using Medical Devices. Part 1-Contact Allergy to Baseline Series Allergens. [PDF]
The contact allergy prevalence in individuals with diabetes and in diabetes medical device (MD) users is unknown. This study in 204 diabetes MD users (114 with rash to diabetes MDs, 90 without) aimed at investigating the contact allergy prevalence to baseline series allergens. Contact allergies to sesquiterpene lactone mix and myroxylon pereirae resin (
Sukakul T +5 more
europepmc +2 more sources

