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Sindbis Virus Platform Provides an Oncolytic-Virus-Mediated and Immunotherapeutic Strategy to Overcome the Challenging Microenvironment of Pancreatic Cancer. [PDF]

Pharmaceuticals (Basel)
Opp S, Pampeno C, Hurtado A, Meruelo D.
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A step towards animal models with self-sustained fungal bioluminescence

Gleneadie HJ, Veland N, Warren EC, Sardini A, Barroso C, Fadeeva AA, Webster Z, Dormann D, Gao F, Martinez-Perez E, Merkenschlager M, Sarkisyan K, Fisher AG.   +12 more
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Fungal oxidation of 3-methylcholanthrene: Formation of proximate carcinogenic metabolites of 3-methylcholanthrene

Chemico-Biological Interactions, 1982
The filamentous fungus, Cunninghamella elegans, was found to metabolize the potent carcinogen, 3-methylcholanthrene (3-MC) to 1-hydroxy-3-MC, 2-hydroxy-3-MC, 1-keto-3-MC, 2-keto-3-MC and trans-9,10-dihydrodiols of 1-hydroxy-3-MC. In addition several unidentified derivatives of 3-MC were found.
D T Gibson, C E Cerniglia
exaly   +3 more sources

The identification of 3-methylcholanthrene-9,10-dihydrodiol as an intermediate in the binding of 3-methylcholanthrene to DNA in cells in culture

Chemico-Biological Interactions, 1978
Two metabolites of 3-methylcholanthrene (3MC), previously shown to be precursors of the DNA-bound form of 3MC observed in embryo cells in culture, were prepared from 3MC by microsomal metabolism and isolated by high pressure liquid chromatography (HPLC).
P Brookes, M R Osborne, M R Osborne
exaly   +3 more sources

Uptake of methylcholanthrene in the rat pancreas

The American Journal of Digestive Diseases, 1974
Epidemiologic studies show an increase in the incidence of pancreatic carcinoma and suggest that this increase may result, at least in part, from increased exposure to chemical carcinogens. Little information is available concerning the uptake of such agents or their effects on the pancreas.
O, Black, P D, Webster
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Metabolism of Radioactive Methylcholanthrene in the Rat

Nature, 1963
IT has long been known that the administration of methylcholanthrene by the alimentary tract can produce mammary tumours in certain strains of mice and rats. Prohaska, Brunschwig and Wilson1 first reported four mammary tumours in 15 mice fed 1.2 mg methylcholanthrene three times weekly for up to six weeks.
A L, FOODALL, M H, McINTYRE, J S, KENNEDY   +2 more
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A Test for Mutagenicity of Methylcholanthrene

Nature, 1948
RECENT results by Strong1,2 and by Carr3 on mice, and by Demerec4 on Drosophila, have focused interest on a possible connexion between mutagenicity and carcinogenicity, which in the past has often been claimed on theoretical grounds. While Auerbach5 failed to produce mutations by injection of 1 : 2 : 5 : 6 dibenzanthracene into Drosophila, Demerec ...
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Synthesis of 3-methylcholanthrene

Tetrahedron Letters, 1981
Abstract A novel synthesis of 3-methylcholanthrene is described which is operationally sipmler than the method in current use and is potentially applicable to the synthesis ofa wide range of other polycyclic hydrocarbons and their cracinogenic metabolites.
Stephen A. Jacobs, Ronald G. Harvey
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Methylcholanthrene causes increased thymocyte apoptosis

Toxicology, 1998
The polycyclic aromatic hydrocarbon (PAH), methylcholanthrene (MCA), is a well studied carcinogen and a teratogen. MCA and other PAH cause immune suppression of B cell and T cell responses in mice and MCA had been reported to induce thymus atrophy. Here we show that MCA treatment causes thymus atrophy in adrenalectomized mice and in C57BL/6 and DBA/2 ...
C T, Lutz, G, Browne, C R, Petzold
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Fluorescence of Methylcholanthrene

Nature, 1942
THE letter on “Fluorescent Lipoidal Spectra of Human Tissue” in NATURE of February 14, p. 193, requires comment upon several points.
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