The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis. [PDF]
FEBS JHere, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Carmona-Carmona CA +11 more
europepmc +2 more sources
Different culture media containing methyldopa for melanin production by Cryptococcus species
Revista da Sociedade Brasileira de Medicina Tropical, 2011 INTRODUCTION: Melanin production by species of Cryptococcus is widely used to characterize C. neoformans complex in mycology laboratories. This study aims to test the efficacy of methyldopa from pharmaceutical tablet as a substrate for melanin production,
Ralciane de Paula Menezes +2 more
doaj +1 more source
Inappropriate Use of Nonpsychotropic Medications in Nursing Homes [PDF]
, 1995 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111070/1/j.1532-5415.1995.tb06098.x ...
Beers +20 more
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The role of antihypertensive drugs in patients with preeclampsia and how to prevent it
Majalah Obstetri dan Ginekologi, 2022 HIGHLIGHTS 1. Preeclampsia, or hypertension in pregnancy, remains a serious problem that has negative short and long-term consequences for the mother and the baby. 2.
I Gde Sastra Winata +2 more
doaj +1 more source
In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia [PDF]
, 2014 Antihypertensive drugs lower the maternal blood pressure in pre-eclampsia (PE) by direct or central vasodilatory mechanisms but little is known about the direct effects of these drugs on placental ...
Gangooly, S +2 more
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Men's Health Journal, 2020 Introduction: Preeclampsia is a specific gestational syndrome that reduces organ perfusion due to vascular spasm and endothelial activation. Despite the use of magnesium sulfate, the patient's blood pressure sometimes remains uncontrolled, and therefore,
Setareh Siamansoori +3 more
doaj +1 more source
Liver rejection and its differentiation from other causes of graft dysfunction. [PDF]
, 1985 Numerous causes can lead to hepatic dysfunction following orthotopic liver transplantation. The most common cause is rejection, which is usually nonpreventable. The clinical presentation, time of onset, and even treatment are variable. Other causes, such
Esquivel, CO +5 more
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Kinetics of dopamine oxidation by sodium N-bromo-p-toluenesulphonamide in acid medium. A mechanistic approach [PDF]
, 2002 The oxidation kinetics of dopamine (DPM) by sodium N-bromo-p-toluenesulphonamide (bromamine-T or BAT) was investigated at 40°C in HClO4 medium. The rate is first order in BAT0, fractional order in DPM0 and inverse fractional in H+.
Puttaswamy, ., Ramachandrappa, R.
core +4 more sources
New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]
, 2016 Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
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UNDULY ENHANCED RESPONSE TO TOLVAPTAN IN A WOMAN SHOWING SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION: AN INVESTIGATION OF POSSIBLE CAUSES [PDF]
, 2017 Objective: To investigate possible causes of an excessive response to tolvaptan in a woman with syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Lanzellotti, Davide +4 more
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