Safety and efficacy of methyldopa and labetalol in controlling blood pressure in hypertensive disorders of pregnancy [PDF]
Background: Hypertensive disorders represent the most common medical complication of pregnancy, with a reported incidence of 6-10% and accounts for 15% of maternal mortality.
Y., Subbaratnam +11 more
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A Low-Resistance Hybrid Nanomaterial Composed of Double-Charged Ionic Liquid and a Layered Double Hydroxide (Type Al/Mg-Dodecyl Sulfate) for Electrochemical Determination of Methyldopa [PDF]
The quantification and electrochemical behavior of methyldopa in tablet and urine samples were carried out using a glassy carbon electrode modified with double-charged ionic liquid and a layered double hydroxide.
Mir Mahdi Abolghasemi +2 more
doaj +1 more source
Concentration and pH dependency of α-methyldopa absorption in rat intestine
The intestinal absorption of α-methyldopa from perfused segments of rat intestine was determined. Jejunal and ileal segments were studied at pH 4.5, 6.0 and 7.4 at an α-methyldopa concentration of 0.01 mM, and at pH 6.0 at concentrations of 0.01, 0.10 ...
J B Dressman, A E Merfeld, G L Amidon
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A new colorimetric method for the determination of methyldopa
A rapid and convenient method is described for the determination of methyldopa in pharmaceutical preparations. This is based on measuring the intensity of the orange colour, developed on reacting methyldopa with thiosemicarbazide in alkaline medium, at ...
R B Salama, S K Wahba Khalil
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Indirect Spectrophotometric Determination of Methyldopa using AuNPs-Cr(VI)
A simple, sensitive, and rapid spectrophotometric method was suggested for the indirect determination of methyldopa. The method depends on the chemical reaction between citrate-stabilized gold nanoparticles and chromium (III) ions, which form during ...
Anfal A. Mohammed, Zeena Z. Al Abdali
doaj +1 more source
A case of an elderly man who developed severe hyponatremia and bone marrow granulomatosis while taking methyldopa is described. The hyponatremia was found to be due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Andrei Braester +3 more
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Incidence of hypertension in Taura, Northern Nigeria: Lessons for our health care
Background: The control of hypertension is very important because it leads to incidence rats reductions for stroke, ischaemic heart disease and renal failure.
NCE Okpala, AMJ Okpala
doaj
Investigation of the Relationship of Some Antihypertensive Drugs with Oxidant/Antioxidant Parameters and DNA Damage on Rat Uterus Tissue [PDF]
Background In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue ...
Suleyman Salman +8 more
doaj
Is the hypothermic effect of α-methyldopa mediated by opioid peptides?
At an ambient temperature of 21 °C α-methyldopa (25–200 mg kg−1) induces a dose-dependent decrease in body temperature in rats. A relationship between adrenergic and opioid neuronal systems has been reported.
F P Nijkamp, J M A Sitsen
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