Results 41 to 50 of about 13,481 (184)

A Heterodimeric Reduced-Ferredoxin-Dependent Methylenetetrahydrofolate Reductase from Syngas-Fermenting Clostridium ljungdahlii

Microbiology Spectrum, 2021
The strict anaerobe Clostridium ljungdahlii can ferment CO or H2/CO2 via the Wood-Ljungdahl pathway to acetate, ethanol, and 2,3‐butanediol. This ability has attracted considerable interest, since it can be used for syngas fermentation to produce ...
Jihong Yi, Haiyan Huang, Jiyu Liang, Rufei Wang, Ziyong Liu, Fuli Li, Shuning Wang   +6 more
doaj   +1 more source

MTHFR (5,10-Methylenetetrahydrofolate reductase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on MTHFR (5,10-Methylenetetrahydrofolate reductase), with data on DNA, on the protein encoded, and where the gene is implicated.
R Saffroy, A Lemoine, B Debuire
openaire   +1 more source

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines. [PDF]

PLoS ONE, 2016
In colorectal cancer chemotherapy, the current standard of care includes combination therapy with 5-fluorouracil (5-FU) and leucovorin (LV). However, the factors that determine the LV-mediated enhancement of 5-FU antitumor activity are not fully ...
Hiroshi Tsukihara, Kenta Tsunekuni, Teiji Takechi   +2 more
doaj   +1 more source

Pro‐Carcinogenic Implications of Folic Acid Supplementation During Chemically Induced Cutaneous Squamous Cell Carcinoma in Mice

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
The findings of the present study indicated that folic acid supplementation may promote skin tumorigenesis through increased proliferation, enhanced DNA damage, and impaired DNA repair mechanisms, but the results are not indicative of any dose response effect.
Neha Arora Chugh, Shashi Bala, Tuhin Mallick, Ashwani Koul   +3 more
wiley   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, Volume 38, Issue 49, 1 September 2026.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Clinical presentation of seven patients with Methylenetetrahydrofolate reductase deficiency

Molecular Genetics and Metabolism Reports, 2020
Methylenetetrahydrofolate reductase deficiency; MTHFR (MIM 236250) is widely studied with more than 200 reported cases up to our knowledge from pediatrics to adult patients.
Nada Aljassim, MD, FCCP, Majid Alfadhel, MD, MHSc, SSC-Ped, ABHS(CH), FCCMG, Marwan Nashabat, MD, Wafa Eyaid, MD, FACMG   +3 more
doaj   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1989-1999, September 2026.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

Erciyes Medical Journal, 2019
Objective: This case control study examined the frequency and distribution of the C677T and A1298C single-nucleotide polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene in Turkish patients with chronic periodontitis.
Gülhan Kocaman, Recep Orbak
doaj   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source