Results 61 to 70 of about 13,481 (184)

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

The influence of age, sex, vitamin B(12), folate levels and methylenetetrahydrofolate reductase C677T genetic mutations on plasma homocysteine in the Chinese population

Haematologica, 2000
BACKGROUND AND OBJECTIVES. Thromboembolic diseases remain a major cause of morbidity and mortality in most countries. The present study was thus conducted to determine the influences of age, sex, the methylenetetrahydrofolate reductase (MTHFR) gene ...
CH Ho
doaj  

Roadmap for Mental Health Treatment Utilizing Pharmacogenomic Testing: Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
Allison P. Swanson, Emily K. Mewborn, Garyung Bae   +2 more
wiley   +1 more source

The Importance of Homozygous Polymorphisms of Methylenetetrahydrofolate Reductase Gene in Romanian Patients with Idiopathic Venous Thromboembolism

Balkan Medical Journal, 2013
Background: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. Aims: We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C ...
Cristina Hotoleanu, Daniela Fodor, Adrian Trifa, Radu Popp   +3 more
doaj   +1 more source

Spinal cord demyelination combined with hyperhomocysteinemia: a case report

Neuropsychiatric Disease and Treatment, 2014
Meimei Hao, Yan Zhang, Shuangxing Hou, Yanling Chen, Ming Shi, Gang Zhao, Yanchun Deng Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Hyperhomocysteinemia (HHcy)
Hao MM, Zhang Y, Hou SX, Chen YL, Shi M, Zhao G, Deng YC   +6 more
doaj  

Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension

International Journal of Hypertension, 2012
Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders.
Javed Y. Fowdar, Marta V. Lason, Attila L. Szvetko, Rodney A. Lea, Lyn R. Griffiths   +4 more
doaj   +1 more source

RELATIONSHIP BETWEEN C677T METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM AND HOMOCYSTEINE IN CEREBRAL PALSY

International Journal of Integrated Health Sciences, 2016
Objective: To observe the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and homocysteine levels in cerebral palsy (CP) children. Methods: This cross-sectional study was conducted in several hospitals, school
Uni Gamayani, M. Hasan Machfoed, Ponpon Idjradinata, Tri Hanggono Achmad   +3 more
doaj   +1 more source

Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report

Case Reports in Neurological Medicine, 2013
In neurofibromatosis type-1 (NF1), cerebrovascular disorders are rarely encountered although vasculopathy is a well-known complication.
Halim Yilmaz, Gulten Erkin, Haluk Gumus, Lutfiye Nalbant   +3 more
doaj   +1 more source

Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province

Research in Molecular Medicine, 2014
Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies.
Mahboobeh Nasiri, Ali Roostaei, Zeinab Ehsanian   +2 more
doaj  

Methylenetetrahydrofolate reductase levels and gene expression in leukemia

Current Issues in Pharmacy and Medical Sciences
Leukemia is a neoplastic disease that affects the proliferation of white blood cells and their progenitors. Folic acid deficiency is well-known as a risk factor for leukemia.
Thabit Jinan, Jasib Anwar, Irhaeem Mudad, Al Rufaie Mohauman Mohammed   +3 more
doaj   +1 more source