Results 11 to 20 of about 9,036 (155)

Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease [PDF]

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Obstructive coronary artery disease (CAD) is characterized by the deposition of atherosclerotic plaque on the coronary artery wall. Its manifestations depend on interactions between environmental and genetic risk factors.
Alexandre Rodrigues Guerzoni, Érika Cristina Pavarino-Bertelli, Moacir Fernandes de Godoy, Carla Renata Graça, Patrícia Matos Biselli, Dorotéia Rossi Silva Souza, Eny Maria Goloni Bertollo   +6 more
doaj   +2 more sources

Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics [PDF]

Arquivos de Neuro-Psiquiatria
Background It is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy (DSP), because some genes are involved in specific biological pathways, acting in ...
Raquel Garcia Rocco da Silva, Marcelo A. Costa Lima, Claudia de Melo Moura, Jorge Luiz Luescher, Ludmila Nascimento Rodrigues Campos, Daniel de Souza e Silva, Márcia Gonçalves Ribeiro   +6 more
doaj   +2 more sources

Dietary reference values for riboflavin:(Scientific Opinion) [PDF]

, 2017
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for riboflavin. The Panel considers that the inflection point in the urinary riboflavin excretion

core   +15 more sources

Characterizing acetogenic metabolism using a genome-scale metabolic reconstruction of [PDF]

, 2013
BACKGROUND: The metabolic capabilities of acetogens to ferment a wide range of sugars, to grow autotrophically on H(2)/CO(2), and more importantly on synthesis gas (H(2)/CO/CO(2)) make them very attractive candidates as production hosts for biofuels and ...
Ali Ebrahim, Derek R Lovley, Harish Nagarajan, Haythem Latif, Juan Nogales, Karsten Zengler, Merve Sahin   +6 more
core   +4 more sources

Association of MTHFR A1298C polymorphism with breast cancer and/or ovarian cancer risk: an updated meta-analysis [PDF]

, 2016
Background: Recent years have witnessed the discovery of similar gene variations between breast cancer and ovarian cancer, inherited breast and ovarian cancer in particular.
Han, Xiao, Kong, Xiangzhen, Li, Rui, Li, Yi, Liu, Bin, Liu, Wei, Ma, Ying   +6 more
core   +5 more sources

The C677 Mutation in Methylene Tetrahydrofolate Reductase Gene: Correlation with Uric Acid and Cardiovascular Risk Factors in Elderly Korean men [PDF]

, 2004
The C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene results in elevated homocysteine levels and, presumably, in increased cardiovascular risk.
Andreassi, Baekgeun Jeong, Brand, Brattstrom, Byoung Gwon Kim, Coull, Culleton, Evers, Freedman, Frosst, Grillo, Hisahide Nishio, Hyeong Ryeol Yoon, Joon Youn Kim, Kang, Kim, Kyeong Hee Kim, Lehto, Malinow, Malinow, Motti, Mudd, Myeong Jin Lee, Okada, Park, Persky, Sang Hwa Lee, Wannamethee, Welch, Wu, Yong Hwan Lee, Young Seoub Hong   +31 more
core   +2 more sources

MTHFR C677T polymorphism analysis: A simple, effective restriction enzyme-based method improving previous protocols [PDF]

, 2019
Background: 5,10-Methylentetrahydrofolate reductase (MTHFR) C677T polymorphism is one of the most studied genetic variations in the human genome. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is one of the most used ...
Antonaros F., Caracausi M., Cicchini E., Cocchi G., Locatelli C., Olivucci G., Pelleri M. C., Piovesan A., Ramacieri G., Strippoli P., Vitale L.   +10 more
core   +1 more source

Methylenetetrahydrofolate reductase and psychiatric diseases

Translational Psychiatry, 2018
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-carbon metabolism involving folate and homocysteine metabolisms. It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as
Lin Wan, Yuhong Li, Zhengrong Zhang, Zuoli Sun, Yi He, Rena Li   +5 more
semanticscholar   +1 more source

MTHFR gene A1298C (rs1801131) polymorphism and its correlations with cerebrospinal fluid biomarkers, cognitive level, and brain structure changes in patients with Alzheimer’s disease [PDF]

精准医学杂志
Objective To investigate the relationship of A1298C (rs1801131) polymorphism in the MTHFR gene encoding methylenetetrahydrofolate reductase with the cerebrospinal fluid β-amyloid 1-42 subtype (Aβ1-42) level, cognitive level, and brain structure changes ...
MA Yuju, HUANG Liangyu, CHEN Jiaru, TAN Lan
doaj   +1 more source

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition

Nature Communications, 2018
The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM).
D. Froese, J. Kopeć, E. Rembeza, Gustavo Arruda Bezerra, A. Oberholzer, T. Suormala, Seraina Lutz, R. Chalk, O. Borkowska, Matthias R. Baumgartner, W. Yue   +10 more
semanticscholar   +1 more source