Results 11 to 20 of about 107,807 (121)

Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source [PDF]

, 2023
Folate intake and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene may affect folate metabolism in ...
Demmelmair, Johann, Bendik, Igor, Wittke, Anja, Obeid, Rima, Warnke, Ines, Schoop, Rotraut, Troesch, Barbara, Koletzko, Berthold, Hecht, Christina   +8 more
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The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts. [PDF]

, 2008
OBJECTIVE: Epidemiological studies have shown that low folate levels are associated with a high body mass index (BMI). These findings have potentially important health implications and warrant further investigation to determine whether a causal ...
Nordestgaard, B, Tybjaerg-Hansen, A, Lewis, Sarah J, Zacho, J., Lawlor, Debbie A, Ebrahim, S, Smith, G.D., Lewis, S.J., Ebrahim, S., Davey Smith, G, Ebrahim, Shah, Tybjaerg-Hansen, A., Leary, SD, Leary, Sam, Ness, Andy, Lawlor, D, Smith, George Davey, Ness, A., Lewis, SJ, Zacho, J, Zacho, Jeppe, Leary, S., Nordestgaard, Børge G, Nordestgaard, B.G., Tybjaerg-Hansen, Anne, Ness, A, Lawlor, D.A.   +26 more
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Prognostic significance of folate metabolism polymorphisms for lung cancer. [PDF]

, 2007
Functional nonsynonymous single-nucleotide polymorphisms (nsSNPs) of folate metabolism genes can influence the methylation of tumour suppressor genes, thereby potentially impacting on tumour behaviour.
El Galta, R, Rudd, MF, Houlston, RS, T Eisen, R el Galta, E L Webb, R S Houlston, Matakidou, A, Bridle, H, M F Rudd, H Bridle, Eisen, T, A Matakidou, Webb, EL   +13 more
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Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues [PDF]

, 1982
Methylenetetrahydrofolate reductase catalyzes the reduction of methylenetetrahydrofolate ot methyltetrahydrofolate. This reaction commits one carbon units to the pathways of adenosylmethionine-dependent methylation in mammalian cells.
Daubner, S. Colette, Matthews, Rowena Green   +1 more
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The correlation between methylenetetrahydrofolate reductase gene 677C > T polymorphism and fetal congenital defects: A meta-analysis

, 2020
Objective To investigate the correlation between the methylenetetrahydrofolate reductase (MTHFR) gene 677C> T polymorphism and fetal congenital ...
Gao Xia, Li Ping, Wang Enxia, Li Dexia
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No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.

, 2007
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion.
Hekim, Nezih, Ozturk, Okuz, Yilmaz, HÜLYA, Zeybek, Umit, Yaylim, Ilhan, İşbir, TURGAY, Ergen, Arzu   +6 more
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High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]

, 2015
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Deng, L, Wu, Q, Greene, ND, Leung, KY, Best, A, Mikael, LG, Malysheva, OV, Christensen, KE, Rozen, R, Lévesque, N, Caudill, MA   +10 more
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Nitrous Oxide Toxicity with Methylenetetrahydrofolate Reductase Deficiency

, 2003
The neurological deterioration and death of a child with methylenetetrahydrofolate reductase (MTHFR) deficiency following anesthetization with nitrous oxide are reported from the University of Wisconsin Medical School, Madison, WI, and McGill University,
J Gordon Millichap, Millichap, J. Gordon
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Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology [PDF]

, 1998
Methylenetetrahydrofolate reductase and cobalamin-dependent methionine synthase catalyze the penultimate and ultimate steps in the biosynthesis of methionine in prokaryotes, and are required for the regeneration of the methyl group of methionine in ...
Sheppard, Christal A., Matthews, Rowena Green, Goulding, C., Sheppard, C., Matthews, R. G.   +4 more
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The 677C \u3e T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice

, 2022
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer\u27s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood.
Nho, Kwangsik, Territo, Paul R, Bottiglieri, Teodoro, Christensen, Karen E, Graham, Leah C, Graham, Leah C., Christensen, Karen E., Howell, Gareth R., Persohn, Scott C., Territo, Paul R., Reagan, Alaina M., Figueiredo, Lucas L, Howell, Gareth R, Bedwell, Amanda A, Reagan, Alaina M, Eldridge, Kierra, Sasner, Michael, Persohn, Scott C, Reagan , Alaina M., Bedwell, Amanda A., Rozen, Rima, Figueiredo, Lucas L., Speedy, Rachael   +22 more
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