Hopanoid-free Methylobacterium extorquens DM4 overproduces carotenoids and has widespread growth impairment. [PDF]
PLoS ONE, 2017 Hopanoids are sterol-like membrane lipids widely used as geochemical proxies for bacteria. Currently, the physiological role of hopanoids is not well understood, and this represents one of the major limitations in interpreting the significance of their ...
Alexander S Bradley +7 more
doaj +2 more sources
Development of an optimized medium, strain and high-throughput culturing methods for Methylobacterium extorquens. [PDF]
PLoS ONE, 2013 Methylobacterium extorquens strains are the best-studied methylotrophic model system, and their metabolism of single carbon compounds has been studied for over 50 years. Here we develop a new system for high-throughput batch culture of M.
Nigel F Delaney +5 more
doaj +2 more sources
Evolution uncovers a general tradeoff between recovery after heat shock and growth at elevated temperatures [PDF]
mBioFitness tradeoffs between different environments enable the maintenance of microbial diversity. While the importance of tradeoffs is clear, it has been surprisingly difficult to predict which traits they will occur between and at how granular a level ...
Akshat Mall +2 more
doaj +2 more sources
Co-consumption of methanol and succinate by Methylobacterium extorquens AM1. [PDF]
PLoS ONE, 2012 Methylobacterium extorquens AM1 is a facultative methylotrophic Alphaproteobacterium and has been subject to intense study under pure methylotrophic as well as pure heterotrophic growth conditions in the past.
Rémi Peyraud +4 more
doaj +2 more sources
Methylobacterium extorquens PA1 utilizes multiple strategies to maintain formaldehyde homeostasis during methylotrophic growth. [PDF]
PLoS GeneticsMetabolic homeostasis is a central organizing principle of physiology whereby dynamic processes work to maintain a balanced internal state. Highly reactive essential metabolites are ideally maintained at equilibrium to prevent cellular damage.
Zachary T Hying +4 more
doaj +2 more sources
Production of 3-hydroxypropionic acid in engineered Methylobacterium extorquens AM1 and its reassimilation through a reductive route [PDF]
Microbial Cell Factories, 2017 Background 3-Hydroxypropionic acid (3-HP) is an important platform chemical, serving as a precursor for a wide range of industrial applications such as the production of acrylic acid and 1,3-propanediol.
Yi-Ming Yang +8 more
doaj +2 more sources
Continuous Culture Adaptation of Methylobacterium extorquens AM1 and TK 0001 to Very High Methanol Concentrations [PDF]
Frontiers in Microbiology, 2019 The bio-economy relies on microbial strains optimized for efficient large scale production of chemicals and fuels from inexpensive and renewable feedstocks under industrial conditions.
Sophia Belkhelfa +14 more
doaj +2 more sources
Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron. [PDF]
ChembiochemThe synthesis and the investigation of the lanthanide (Ln) and Fe‐binding properties of the putative lanthanophore methylolanthanin (MLL) and the siderophore rhodopetrobactin B (RPB B) are reported. While both chelators bind Lns, they unexpectedly precipitate with Lns under biologically relevant conditions and thereby challenge the proposed classic ...
Gutenthaler-Tietze SM +9 more
europepmc +2 more sources
Metabolomics Revealed an Association of Metabolite Changes and Defective Growth in Methylobacterium extorquens AM1 Overexpressing ecm during Growth on Methanol. [PDF]
PLoS ONE, 2016 Methylobacterium extorquens AM1 is a facultative methylotroph capable of growth on both single-carbon and multi-carbon compounds. The ethylmalonyl-CoA (EMC) pathway is one of the central assimilatory pathways in M.
Jinyu Cui +6 more
doaj +2 more sources
Conformational changes on substrate binding revealed by structures of Methylobacterium extorquens malate dehydrogenase [PDF]
Acta Crystallographica Section F, Structural Biology Communications, 2018 Javier M Gonzalez +2 more
exaly +2 more sources