Methanol Dehydrogenases as a Key Biocatalysts for Synthetic Methylotrophy [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 One-carbon (C1) chemicals are potential building blocks for cheap and sustainable re-sources such as methane, methanol, formaldehyde, formate, carbon monoxide, and more.
Thien-Kim Le, Soo-Jin Yeom
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Genomics of Methylotrophy in Gram-Positive Methylamine-Utilizing Bacteria [PDF]
Microorganisms, 2015 Gram-positive methylotrophic bacteria have been known for a long period of time, some serving as model organisms for characterizing the specific details of methylotrophy pathways/enzymes within this group. However, genome-based knowledge of methylotrophy
Mary Lidström +2 more
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Methylotrophy in the Mire: direct and indirect routes for methane production in thawing permafrost [PDF]
MSystemsWhile wetlands are major sources of biogenic methane (CH4), our understanding of resident microbial metabolism is incomplete, which compromises the prediction of CH4 emissions under ongoing climate change. Here, we employed genome-resolved multi-omics to
Kelly Wrighton +2 more
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Beneath the surface: expanding the known repertoire of methylotrophic metabolism [PDF]
Applied and Environmental MicrobiologyAlthough the metabolic pathways that allow the utilization of one-carbon compounds as sole sources of carbon and energy (methylotrophy) are well characterized, this understanding has been substantially refined and expanded in recent years.
Eric L. Bruger, Jannell V. Bazurto
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Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy
Microorganisms, 2022 Formaldehyde metabolism is prevalent in all organisms, where the accumulation of formaldehyde can be prevented through the activity of dissimilation pathways.
Marina Gil Lopez +2 more
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Diel cycle of lanthanide-dependent methylotrophy by TMED127/Methylaequorales bacteria in oligotrophic surface seawater [PDF]
Applied and Environmental MicrobiologyMethanol, the simplest alcohol, has long been known to be a key energy and carbon source for soil and plant-associated bacteria and fungi and is increasingly recognized as an important substrate for marine bacteria.
Jennifer B. Glass +2 more
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Identification of overoxidizing and non-overoxidizing NAD-dependent methanol dehydrogenases and implications for synthetic methylotrophy [PDF]
Nature CommunicationsSynthetic methylotrophy offers opportunities for sustainable chemical and biofuel production. While recently established methylotrophic E. coli can grow on methanol, undesirable formate accumulation occurs during growth and bioproduction.
Philipp Keller +10 more
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Synthetic methylotrophic yeasts for the sustainable fuel and chemical production [PDF]
Biotechnology for Biofuels and Bioproducts, 2022 Global energy-related emissions, in particular carbon dioxide, are rapidly increasing. Without immediate and strong reductions across all sectors, limiting global warming to 1.5 °C and thus mitigating climate change is beyond reach.
Vanessa Wegat +2 more
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Aromatic acid metabolism in Methylobacterium extorquens reveals interplay between methylotrophic and heterotrophic pathways [PDF]
Applied and Environmental MicrobiologyEfforts toward microbial conversion of lignin to value-added products face many challenges because lignin’s methoxylated aromatic monomers release toxic C1 byproducts such as formaldehyde.
Alekhya M. Govindaraju +1 more
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Genetic and phenotypic comparison of facultative methylotrophy between Methylobacterium extorquens strains PA1 and AM1. [PDF]
PLoS ONE, 2014 Methylobacterium extorquens AM1, a strain serendipitously isolated half a century ago, has become the best-characterized model system for the study of aerobic methylotrophy (the ability to grow on reduced single-carbon compounds).
Dipti D Nayak, Christopher J Marx
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