Results 61 to 70 of about 40,562 (182)

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

Decreased dopamine activity predicts relapse in methamphetamine abusers. [PDF]

, 2012
Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated.
Alia-Klein, N, Fowler, JS, Hoffman, W, Jayne, M, Logan, J, Smith, L, Telang, F, Thanos, P, Tomasi, D, Volkow, ND, Wang, GJ, Wong, CT   +11 more
core   +1 more source

When patients with Creutzfeldt–Jakob disease are misdiagnosed as having nonconvulsive status epilepticus

Epilepsia, Volume 66, Issue 4, Page 1006-1013, April 2025.
Abstract Contemporary studies report nonconvulsive status epilepticus (NCSE) in Creutzfeldt–Jakob disease (CJD), based on benzodiazepine (BZP)‐responsive epileptiform discharges on the electroencephalogram (EEG), with the following false syllogism: (1) intravenous (IV) administration of BZPs usually suppress ictal activity in NCSE; (2) in CJD, periodic
Philippe Gélisse, Arielle Crespel
wiley   +1 more source

Performance deficits of NK1 receptor knockout mice in the 5 choice serial reaction time task: effects of d Amphetamine, stress and time of day. [PDF]

, 2011
Background The neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD).
A Blokland, A Castañé, AA Harrison, AJ Mayorga, AS Fisher, BJ Cole, C De Felipe, C Orsini, CA Winstanley, CA Winstanley, CJ Vaidya, David N. Stephens, DE May, DJ Heal, E Calcagno, Ewelina M. Grabowska, EY Pioli, F Pollier, FX Castellanos, G Aston-Jones, G Mick, G Polanczyk, G Renoldi, GA Higgins, H Caci, HD Piggins, I Herpfer, I Tsutsui-Kimura, JA Milstein, JL Evenden, JM Finlay, Julia A. Dudley, JW Dalley, JW Dalley, K Schwabe, KJ Anderson, KJ Radonovich, L Bizarro, L Bizarro, M Carli, M Pum, ME Toplak, MH Teicher, MM Van Veen, N Froger, N Singewald, NM De Bruin, R Kuczenski, R Tannock, RD Oades, RE Mattison, RL Gannon, Ruth K. Weir, S Bejerot, S Body, S Houghton, S Houghton, S Patel, S. Clare Stanford, SC Wood, SI Sharp, SJ Yang, Stephen P. Hunt, T Humby, T Koskinen, T Sagvolden, Tamzin L. Ripley, TC Yan, TC Yan, Ting Carrie Yan, Warren H. Meck, X Xu, Yolanda Peña-Oliver, YP Oliver   +73 more
core   +3 more sources

ADDH And Methylphenidate Response

Pediatric Neurology Briefs, 1994
The dose-response, clinical effectiveness, and response prediction in 76 children with ADDH treated with methylphenidate (MPH) were evaluated by a double-blind, placebo-controlled, crossover study at the Department of Psychology, University of Hawaii, Honolulu.
openaire   +4 more sources

The Effect of SPECTROM Training on Support Staff Knowledge of Psychotropic Medicine and Attitude Towards Behaviours That Challenge in Adults With Intellectual Disabilities to Help Implement the STOMP Initiative

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Overmedication of adults with intellectual (learning) disabilities, particularly the off‐licence use of psychotropic medicines for behaviours that challenge in the absence of a psychiatric disorder, is a major public health concern and an example of health inequalities.
B. Limbu, S. Deb, J. Bradshaw, V. Cooper
wiley   +1 more source

The Separate or Concurrent Effects of Methylphenidate and Alcohol on Acquisition and Retention of the Morris Water Maze in Adolescent Rats [PDF]

, 2014
Alcohol’s (A) capacity to impair learning and memory has been well documented in the Morris Water Maze (MWM) but few studies have examined methylphenidate’s (MPH) impact on MWM performance (Haidun et al., 2010; Zeise et al., 2007).
Creech, Matthew K., Scott, Lindsay
core   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

The Impact of Acute National Stress on Awake Bruxism Behaviour Among Young Adults—An Ecological Momentary Assessment Study

Journal of Oral Rehabilitation, EarlyView.
ABSTRACT Background Awake bruxism (AB) is characterised by repetitive jaw muscle activity during wakefulness and is influenced by various stressors. Objective To investigate the effect of national stress (war) on AB muscle behaviours in young adults, the study was planned as a repeated cross‐sectional study. Methods Two groups were compared: one during
Emodi‐Perlman Alona, Ventura Noa, Czygrinow Anna‐Yael, Manfredini Daniele, Bracci Alessandro, Shalev‐Antshel Tamar, Eli Ilana   +6 more
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source