Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment
Advanced Science, Volume 13, Issue 1, 5 January 2026.Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr. +20 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract Venanprubart (LY3361237), an agonist antibody to B and T lymphocyte attenuator (BTLA), was developed as a potential treatment for autoimmune disorders, including systemic lupus erythematosus (SLE) and psoriasis. We tested venanprubart in three human Phase 1 safety studies: a single ascending dose (SAD) study in healthy participants (1/2/5/15 ...
Andrew C. Vendel +9 more
wiley +1 more source
Epidemiological Effectiveness and Cost of a Fungal Meningitis Outbreak Response in New River Valley, Virginia: Local Health Department and Clinical Perspectives. [PDF]
, 2017 OBJECTIVE: We evaluated the effectiveness and cost of a fungal meningitis outbreak response in the New River Valley of Virginia during 2012-2013 from the perspective of the local public health department and clinical facilities.
Abbas, Kaja M +5 more
core +1 more source
Treatment of chalazia: a comparison between incision and curettage and intralesional methylprednisolone injection [PDF]
, 2008 Purpose The study was conducted to compare intralesional methylprednisolone acetate 40 mg/ml (Depo-Medrol) injection with incision and curettage in the treatment of chalazia. Method A prospective, interventional clinical study was conducted.
Roodt, Herman
core
Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography [PDF]
, 2010 Poly(N-vinylcaprolactam) (PVCL) connected to aminopropyl silica is a new stationary phase for temperature responsive liquid chromatography (TR-LC). PVCL shows a transition from hydrophilic to hydrophobic interaction between 30 and 40 degrees C.
Euerby, Melvin +4 more
core +1 more source
A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing [PDF]
, 2017 TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the ...
Agmon-Levin +85 more
core +2 more sources
Percutaneous Method of Management of Simple Bone Cyst [PDF]
, 2013 Introduction. Simple bone cyst or unicameral bone cysts are benign osteolytic lesions seen in metadiaphysis of long bones in growing children. Various treatment modalities with variable outcomes have been described in the literature.
O. P. Lakhwani
core +1 more source
Preliminary experience on systemic effects of perineural dexamethasone sodium phosphate and methylprednisolone acetate through adductor canal block in total knee arthroplasty: A single center retrospective study. [PDF]
J Anaesthesiol Clin Pharmacol, 2023 Li J, Dai F, Zhou B, Cortes M, Baldev K.
europepmc +1 more source
Corticosteroids for the management of cancer-related pain in adults (Review) [PDF]
, 2015 Background: One of the most feared symptoms associated with cancer is pain. Opioids remain the mainstay of pain treatment but corticosteroids are often used concurrently as co- or adjuvant analgesics.
Good, Phillip +6 more
core +1 more source