Results 301 to 310 of about 365,379 (338)
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1968
An enzyme that transfers the methyl group of S-adenosylmethionine to phenol to form anisole is described. The enzyme is highly localized in the microsomes of the liver and lung of mammals and is also present in other tissues. A variety of simple alkyl-, methoxy- and halophenols can serve as substrates for the phenol-O-methylating enzyme.
J, Axelrod, J, Daly
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An enzyme that transfers the methyl group of S-adenosylmethionine to phenol to form anisole is described. The enzyme is highly localized in the microsomes of the liver and lung of mammals and is also present in other tissues. A variety of simple alkyl-, methoxy- and halophenols can serve as substrates for the phenol-O-methylating enzyme.
J, Axelrod, J, Daly
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EUKARYOTIC CYTOSINE METHYLTRANSFERASES
Annual Review of Biochemistry, 2005▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is ...
Mary Grace, Goll, Timothy H, Bestor
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Plant Molecular Biology, 2000
DNA methylation is an important modification of DNA that plays a role in genome management and in regulating gene expression during development. Methylation is carried out by DNA methyltransferases which catalyse the transfer of a methyl group to bases within the DNA helix.
E J, Finnegan, K A, Kovac
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DNA methylation is an important modification of DNA that plays a role in genome management and in regulating gene expression during development. Methylation is carried out by DNA methyltransferases which catalyse the transfer of a methyl group to bases within the DNA helix.
E J, Finnegan, K A, Kovac
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2011
DNA methyltransferases are important enzymes and their inhibition has many potential applications. The investigation of DNA methyltransferases as well as screening for potential inhibitors requires specialized enzyme assays. In this chapter, we describe three DNA methyltransferase assays, each of them based on a different method: (1) An assay using ...
Renata Z, Jurkowska +4 more
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DNA methyltransferases are important enzymes and their inhibition has many potential applications. The investigation of DNA methyltransferases as well as screening for potential inhibitors requires specialized enzyme assays. In this chapter, we describe three DNA methyltransferase assays, each of them based on a different method: (1) An assay using ...
Renata Z, Jurkowska +4 more
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Elongation factor methyltransferase 3 – A novel eukaryotic lysine methyltransferase
Biochemical and Biophysical Research Communications, 2014Here we describe the discovery of Saccharomycescerevisiae protein YJR129Cp as a new eukaryotic seven-beta-strand lysine methyltransferase. An immunoblotting screen of 21 putative methyltransferases showed a loss in the methylation of elongation factor 2 (EF2) on knockout of YJR129C.
Lelin, Zhang +4 more
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Sea urchin DNA methyltransferases
Cell Biophysics, 1989DNA methyltransferase activities have been partially purified from unfertilized eggs and blastula nuclei of sea urchin embryos. Comparative studies, using different DNAs as substrates, show that the two preparations are most active on hemimethylated and single-strand DNA, but they methylate, though at a lower rate, also on double-strand DNA.
Tosi L +5 more
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Cobalamin-Dependent Methyltransferases
Accounts of Chemical Research, 2001Cobalamin cofactors play critical roles in radical-catalyzed rearrangements and in methyl transfers. This Account focuses on the role of methylcobalamin and its structural homologues, the methylcorrinoids, as intermediaries in methyl transfer reactions, and particularly on the reaction catalyzed by cobalamin-dependent methionine synthase.
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Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase
Cellular and Molecular Neurobiology, 20061. Pharmacogenomics is the study of the role of inheritance in variation in the drug response phenotype-a phenotype that can vary from adverse drug reactions at one end of the spectrum to lack of therapeutic efficacy at the other. 2. The thiopurine S-methyltransferase (TPMT) genetic polymorphism represents one of the best characterized and most ...
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