Results 61 to 70 of about 365,379 (338)

Identification and Characterization of Zika Virus NS5 Methyltransferase Inhibitors

Frontiers in Cellular and Infection Microbiology, 2021
The recurring outbreak of Zika virus (ZIKV) worldwide makes an emergent demand for novel, safe and efficacious anti-ZIKV agents. ZIKV non-structural protein 5 (NS5) methyltransferase (MTase), which is essential for viral replication, is regarded as a ...
Weibao Song, Hongjuan Zhang, Yu Zhang, Ying Chen, Yuan Lin, Yanxing Han, Jiandong Jiang   +6 more
doaj   +1 more source

Cullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma [PDF]

, 2022
Xiuying Sun, Jinhui Zhou, Zhicun Zhang
openalex   +1 more source

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase [PDF]

, 1991
Mammalian DNA cytosine-5-methyltransferase (MTase, EC 2.1.1.37) is an essential component for establishing and maintaining cell-type specific methylation patterns in the genome. The cDNAfor the murine enzyme was previously cloned in segments.
Berg, Bestor, Bestor, Bestor, Boshart, Bradford, Cedar, de Villiers, Gluzman, Hergersberg, Kingston, Klempnauer, Matthias, Mellon, Morgenstern, Müller, Pfeifer, Pfeifer, Pósfai, Severne   +19 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A recognition of exosomes as regulators of epigenetic mechanisms in central nervous system diseases

Frontiers in Molecular Neuroscience
Exosomes, vesicular structures originating from cells, participate in the conveyance of proteins and nucleic acids. Presently, the centrality of epigenetic modifications in neurological disorders is widely acknowledged.
Shunxin Hu, Lei Feng, Zhonghong Yang, Xuechen Fan, Haozheng Gao, Tiancai Yang   +5 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Competing Methyltransferase Systems

Journal of Biological Chemistry, 1972
Abstract Large differences between the transfer RNA methyl-transferase capacity of adult organs and their fetal counterparts, as well as between tumor tissues and normal tissues, have been observed. This is in part due to the presence of natural inhibitors of the tRNA methyltransferases in normal adult tissues. An inhibitory system present in the liver,
openaire   +2 more sources

The Comparison of Catechol-o-methyltransferase VAL158MET on Schizophrenic Bataknese Patients [PDF]

, 2023
David Erickson Simanjuntak, Elmeida Effendy, Mustafa M. Amin   +2 more
openalex   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source