Multisite Population Epigenetic Model of Passive Demethylation [PDF]
arXiv, 2012 The methylation of DNA regulates gene expression. On cell division the methylation state of the DNA is typically inherited from parent to daughter cells. While the chemical bond between the methyl group and the DNA is very strong, changes to the methylation state do occur and are observed to occur rapidly in response to external stimulus.
arxiv
Systematically Dissecting the Global Mechanism of miRNA Functions in Pluripotent Stem Cells [PDF]
arXiv, 2012 MicroRNAs (miRNAs) critically modulate stem cell properties like pluripotency, but the fundamental mechanism remains largely unknown. This study systematically analyzes multiple-omics data and builds a systems physical network including genome-wide interactions between miRNAs and their targets to reveal the systems mechanism of miRNA functions in mouse
arxiv
A Statistical Approach to Identifying Significant Transgenerational Methylation Changes [PDF]
arXiv, 2014 Epigenetic aberrations have profound effects on phenotypic output. Genome wide methylation alterations are inheritable to pass down the aberrations through multiple generations. We developed a statistical method, Genome-wide Identification of Significant Methylation Alteration, GISAIM, to study the significant transgenerational methylation changes ...
arxiv
A comparative analysis of DNA methylation in diploid and tetraploid apple (Malus × domestica Borkh.)
Czech Journal of Genetics and Plant Breeding, 2017 DNA methylation is one of the major epigenetic modifications. It is very important to the regulation of gene expression. Methylation-sensitive amplification polymorphism (MSAP) profiling was applied to a diploid apple cultivar and its derived ...
Ping HE +4 more
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A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
eLife, 2016 Histone lysine-to-methionine (K-to-M) mutations are associated with multiple cancers, and they function in a dominant fashion to block the methylation of corresponding lysines on wild type histones. However, their mechanisms of function are controversial.
Chun-Min Shan +10 more
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DNA methylation variation in Arabidopsis has a genetic basis and shows evidence of local adaptation [PDF]
arXiv, 2014 Epigenome modulation in response to the environment potentially provides a mechanism for organisms to adapt, both within and between generations. However, neither the extent to which this occurs, nor the molecular mechanisms involved are known. Here we investigate DNA methylation variation in Swedish Arabidopsis thaliana accessions grown at two ...
arxiv
Frontiers in Plant ScienceMonoterpenoid indole alkaloids (MIA) are one of the largest and most complex alkaloid class in nature, boasting many clinically significant drugs such as anticancer vinblastine and antiarrhythmic ajmaline.
Maisha Farzana +6 more
doaj +1 more source
Robust transfer regression with corrupted labels [PDF]
arXivIn this paper, we introduce a robust transfer regression method designed to handle corrupted labels in target data, under the scenarios that the corruption affects a substantial portion of the labels and the locations of these corruptions are unknown.
arxiv
Comparative Analysis of 2D and 3D ResNet Architectures for IDH and MGMT Mutation Detection in Glioma Patients [PDF]
arXivGliomas are the most common cause of mortality among primary brain tumors. Molecular markers, including Isocitrate Dehydrogenase (IDH) and O[6]-methylguanine-DNA methyltransferase (MGMT) influence treatment responses and prognosis. Deep learning (DL) models may provide a non-invasive method for predicting the status of these molecular markers.
arxiv
Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis. [PDF]
World J Gastrointest OncolXin MJ, Yuan Y.
europepmc +1 more source