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Unveiling the Role of Histone Methyltransferases in Psoriasis Pathogenesis: Insights from Transcriptomic Analysis. [PDF]
Int J Mol SciRomhányi D +5 more
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The Future of Epigenetics: Emerging Technologies and Clinical Applications. [PDF]
ACS Pharmacol Transl SciIyer KA +5 more
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Characterisation of the N-Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines. [PDF]
Angew Chem Int Ed EnglChapple BP +7 more
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Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS. [PDF]
FASEB JWeng Y +12 more
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Eukaryotic cytosine methyltransferases.
Annual Review of Biochemistry, 2005▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is ...
M. Goll, T. Bestor
semanticscholar +3 more sources
Canadian Journal of Biochemistry and Physiology, 1963
The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase,
J, BLUMENSTEIN, G R, WILLIAMS
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The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase,
J, BLUMENSTEIN, G R, WILLIAMS
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Current Opinion in Cell Biology, 1994
Mammals have long been known to tag their DNA by the addition of methyl groups to cytosine residues. Only quite recently, however, has the functional significance of DNA methylation established a firm footing. Evidence now indicates that DNA methylation is essential for development, and is involved in both programmed and ectopic gene inactivation ...
T H, Bestor, G L, Verdine
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Mammals have long been known to tag their DNA by the addition of methyl groups to cytosine residues. Only quite recently, however, has the functional significance of DNA methylation established a firm footing. Evidence now indicates that DNA methylation is essential for development, and is involved in both programmed and ectopic gene inactivation ...
T H, Bestor, G L, Verdine
openaire +2 more sources
Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
R M, Weinshilboum +2 more
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▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
R M, Weinshilboum +2 more
openaire +2 more sources