Results 11 to 20 of about 16,608 (178)
Progress in Gastroparesis Management: From Pharmacotherapy to Interventional Treatments. [PDF]
JGH OpenABSTRACT Gastroparesis is a sensorimotor condition characterized by delayed gastric emptying without any obvious mechanical obstruction. Common symptoms include early satiety, nausea, vomiting, belching, and bloating. The most frequent causes of gastroparesis are diabetes, idiopathic factors, and post‐surgical complications.
Kumar G +9 more
europepmc +2 more sources
Results of a Phase 1 Study Assessing the Effect of CIN-102, a Novel Formulation of the Dopamine Receptor Antagonist Domperidone Designed to Treat Gastroparesis, on Cardiac Repolarization in Healthy Volunteers. [PDF]
Clin Pharmacol Drug DevAbstract CIN‐102 is a deuterated form of domperidone in development for the treatment of acute, recurrent gastroparesis. This thorough QT study assessed the effects of CIN‐102 on cardiac repolarization in 62 healthy volunteers. In this 4‐period randomized crossover study, participants were administered single doses of 30‐mg CIN‐102 (representing ...
Bond M +6 more
europepmc +2 more sources
BMC Neurology, 2023 Background Many drugs are prescribed in relieving acute migraine attacks, we aim to compare metoclopramide with other antimigraine drugs. Methods We searched online databases like PubMed, Cochrane Library, Scopus, and Web of Science till June 2022 for ...
Hanaa Abdelmonem +8 more
doaj +1 more source
BMC Pharmacology and Toxicology, 2020 Background Cola nitida is commonly chewed in many West African cultures to ease hunger pangs and sometimes for their stimulant and euphoriant qualities.
Cecilia Nwadiuto Amadi +1 more
doaj +1 more source
Metoclopramide-induced central nervous system depression in the chicken
BMC Veterinary Research, 2005 Background Metoclopramide is a dopamine D2-receptor antagonist used as an antiemetic and gastroprokinetic agent in man and animals. The drug causes sedation as a side effect in man.
Mohammad Fouad K, Al-Zubaidy Muna HI
doaj +1 more source
International Journal of Pediatrics, 2021 Background. Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates. The main clinical manifestations of neonatal GERD are frequent regurgitation or vomiting associated with irritability, crying, anorexia or feeding refusal,
Peymaneh Alizadeh Taheri +2 more
doaj +1 more source
Intravenous Use of Metoclopramide and Sustained Hypotension: A Case Report [PDF]
Patient Safety and Quality Improvement Journal, 2021 Introduction: Transient hypotension has been commonly associated with metoclopramide hydrochloride, particularly with intravenous use. However, the risk of sustained hypotension that lasts for hours has not been previously associated with metoclopramide,
Mulugeta Russom, Okbu Frezgi
doaj +1 more source
Interaction between metoclopramide and toxicity of diazinon in mice [PDF]
Iraqi Journal of Veterinary Sciences, 2007 The aim of the study was to examine the interaction and toxicity between metoclopramide and organophosphorus insecticide diazinon in mice using the up and down method.
M. H. I. Alzubaidy
doaj +1 more source
Metoclopramide in Gastroparesis: Its Mechanism of Action and Safety Profile
Gastrointestinal Disorders, 2023 Metoclopramide has been the cornerstone of gastroparesis management for the past 40 years as it is the only FDA-approved medication for gastroparesis. Other medications such as erythromycin and domperidone have been used off-label with variable efficacy.
M Ammar Kalas +4 more
doaj +1 more source
Turkish Journal of Emergency Medicine, 2017 Objectives: One of the irritating features of migraine is emesis that can compromise taking oral medications. We designed this study to compare the effectiveness of granisetron and metoclopramide in reducing pain and treating emesis in migraine patients.
Hassan Amiri +4 more
doaj +1 more source