Results 1 to 10 of about 70,021 (330)
Human Genomics, 2020 Introduction Metoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases.
Chad N. Brocker +9 more
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Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care. [PDF]
Pharmacol Res PerspectABSTRACT Bisoprolol is a second‐generation, highly selective beta‐1 adrenergic receptor antagonist with various beneficial effects in patients with heart failure. Interindividual variability in response to bisoprolol is known, and finding the optimal dose for individual patients with heart failure is still challenging.
Kacirova I +5 more
europepmc +2 more sources
A Comprehensive CYP2D6 Drug-Drug-Gene Interaction Network for Application in Precision Dosing and Drug Development. [PDF]
Clin Pharmacol TherConducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these interactions. Here, physiologically‐based pharmacokinetic (PBPK) modeling networks present a new avenue for exploring such complex scenarios, potentially informing ...
Rüdesheim S +14 more
europepmc +2 more sources
Metoprolol use is associated with improved outcomes in patients with sepsis-induced cardiomyopathy: an analysis of the MIMIC-IV database. [PDF]
BMC Cardiovasc DisordBackground Metoprolol is commonly administered to critically ill patients; however, its effect on mortality in patients with sepsis-induced cardiomyopathy (SICM) remains uncertain.
Zhong L, Zhong Y, Liao Y, Zhou Y.
europepmc +2 more sources
Disposition of metoprolol in the newborn [letter] [PDF]
British Journal of Clinical Pharmacology, 1981 M Ervik +4 more
openaire +4 more sources
A higher peak heart rate during head-up tilt test predicts the therapeutic efficacy of metoprolol in vasovagal syncope. [PDF]
BMC Cardiovasc DisordBackground Although beta blockers, such as metoprolol, have been widely used in the management of vasovagal syncope (VVS), their efficacy remains debated, with larger studies showing limited benefit.
Liu K +8 more
europepmc +2 more sources
Frontiers in Cardiovascular Medicine, 2022 ObjectivesThe study was designed to explore the role of baseline-corrected QT interval dispersion (QTcd) in predicting the effectiveness of metoprolol on pediatric postural tachycardia syndrome (POTS).MethodsThere were two groups in the study, the ...
Yuanyuan Wang +10 more
doaj +1 more source
Metoprolol rescues endothelial progenitor cell dysfunction in diabetes [PDF]
PeerJ, 2020 Added risk portended by diabetes in addition to hypertension has been related to an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the endothelial function compared with a placebo.
Lang Yan +12 more
doaj +2 more sources
Pharmacology Research & Perspectives, 2023 Small studies suggest that amiodarone is a weak inhibitor of cytochrome P450 (CYP) 2D6. Inhibition of CYP2D6 leads to increases in concentrations of drugs metabolized by the enzyme, such as metoprolol. Considering that both metoprolol and amiodarone have
Sabrina Robert +11 more
doaj +1 more source