Results 11 to 20 of about 70,021 (330)

Heart Rate Variability Predicts Therapeutic Response to Metoprolol in Children With Postural Tachycardia Syndrome

Frontiers in Neuroscience, 2019
PurposeTo improve the metoprolol therapeutic effectiveness, we aimed to explore whether baseline heart rate variability (HRV) indicators before metoprolol treatment were useful for predicting its efficacy for postural tachycardia syndrome (POTS ...
Yuanyuan Wang, Yuanyuan Wang, Chunyu Zhang, Selena Chen, Ping Liu, Yuli Wang, Chaoshu Tang, Chaoshu Tang, Hongfang Jin, Hongfang Jin, Junbao Du, Junbao Du   +11 more
doaj   +2 more sources

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Frontiers in Pharmacology, 2018
Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin.
Benjamin Berger, Benjamin Berger, Fabio Bachmann, Fabio Bachmann, Urs Duthaler, Urs Duthaler, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl, Manuel Haschke, Manuel Haschke   +10 more
doaj   +2 more sources

Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents

Molecules, 2018
The solubilities of metoprolol succinate (a cardioselective β1 adrenergic receptor) in methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl acetate, and acetone were measured at temperatures ranging from (278.2 to 318.2) K using a solid ...
Jian Shen, Xianrui Liang, Hao Lei
doaj   +2 more sources

Metoprolol exerts a non-class effect against ischaemia–reperfusion injury by abrogating exacerbated inflammation

European Heart Journal, 2020
Aims Clinical guidelines recommend early intravenous β-blockers during ongoing myocardial infarction; however, it is unknown whether all β-blockers exert a similar cardioprotective effect.
A. Clemente-Moragón, Mónica Gómez, Rocío Villena-Gutiérrez, D. V. Lalama, J. García‐Prieto, F. Martínez, F. Sánchez-Cabo, V. Fuster, E. Oliver, B. Ibáñez   +9 more
semanticscholar   +1 more source

Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries

Brazilian Journal of Pharmaceutical Sciences, 2023
Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore,
Ghazaleh Sadrhaghighi, Samin Abbaszadeh, Shabnam Babataheri, Alireza Garjani, Hamid Soraya   +4 more
doaj   +1 more source

Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study

Clinical and Translational Science, 2022
Large, observational genetic studies are commonly used to identify genetic factors associated with diseases and disease‐related traits. Such cohorts have not been commonly used to identify genetic predictors of drug dosing or concentrations, perhaps ...
Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus   +9 more
doaj   +1 more source

Green spectrofluorimetric quantification of aspirin, olmesartan, and metoprolol in spiked human plasma

Scientific Reports, 2023
Low dose aspirin is routinely taken with antihypertensive drugs such as olmesartan and metoprolol to avoid the cardiovascular and renal outcomes associated with high blood pressure. The first spectrofluorimetric method for quantifying aspirin, olmesartan,
Ali Alqahtani, Taha Alqahtani, Reem M. Gahtani, Sherif Ramzy   +3 more
doaj   +1 more source

CYP2D6 polymorphism and its impact on the clinical response to metoprolol: A systematic review and meta-analysis.

British Journal of Clinical Pharmacology, 2020
CYP2D6 genetic polymorphisms are associated with metoprolol pharmacokinetics. Whether the clinical response to metoprolol is also affected remains uncertain. METHODS We conducted a systematic review on the effects of CYP2D6 polymorphism on the clinical
Maxime Meloche, Michael Khazaka, Imad Kassem, Amina Barhdadi, M. Dubé, S. de Denus   +5 more
semanticscholar   +1 more source

Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core [PDF]

, 2014
A
De Beer, Thomas, Dierickx, Lien, Gonnissen, Yves, Remon, Jean Paul, Saerens, Lien, Vervaet, Chris, Voorspoels, Jody, Vynckier, An-Katrien   +7 more
core   +2 more sources

Metoprolol for Aggression

Journal of the American Academy of Child & Adolescent Psychiatry, 1992
Journal of the American Academy of Child & Adolescent Psychiatry 31 (1992) 994-994.
University of Florida, Jacksonville ( host institution ), Matthews-Ferrari, Katina, Karroum, Nabil   +2 more
openaire   +4 more sources