Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial. [PDF]
, 2016 AimsIn this analysis, we utilized data from PARADIGM-HF to test the hypothesis that participants who exhibited any dose reduction during the trial would have similar benefits from lower doses of sacubitril/valsartan relative to lower doses of enalapril ...
Claggett, Brian +12 more
core +1 more source
Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study [PDF]
, 1994 Objectives. This study examined the of metoprolol on left ventricular performance, efficiency, neurohormonal activation and myocardial respiratory quotient in patients with dilated cardiomyopathy.Background.The mechanism by which beta-adrenergie blockade
Alvarez, Luis G. +8 more
core +1 more source
Clinico-pharmacological aspects of metoprolol use
Системные гипертензии, 2013 Over the years b-blocker metoprolol is one of the commonly prescribed drugs for the treatment of various cardiovascular pathologies . The following review article discusses the classification of b-blockers , and pharmacokinetics of two metoprolol forms ...
G S Anikin, I M Chernova, V G Vinokurov
doaj
Use of beta-blockers for the treatment of cardiovascular diseases: focus on metoprolol
Медицинский совет, 2015 The article tells about the mechanisms of action of beta-blockers. Pharmacokinetic, pharmacodynamic and interaction properties of metoprolol are discussed.
O. D. Ostroumova, V. M. Fomina
doaj +1 more source
Navigating Pharmacogenomic Testing in Practice: Who to Test and When to Test
Clinical Pharmacology &Therapeutics, EarlyView.There is increasing attention on the clinical utility and value of pharmacogenetic (PGx) testing to individualize medication management. Most clinical practice guidelines from medical professional societies do not recommend routine PGx testing, with a few key exceptions.
James M. Stevenson +4 more
wiley +1 more source
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019 Background Whether chronic obstructive sleep apnea (OSA) could promote epicardial adipose tissue (EAT) secretion of profibrotic adipokines, and thereby contribute to atrial fibrosis, and the potential therapeutic effects of metoprolol remain unknown ...
Hui Dai +10 more
semanticscholar +1 more source
Absence of beneficial effect of intravenous metoprolol given during angioplasty in patients with single-vessel coronary artery disease [PDF]
, 1993 In a double-blind, randomized, placebo-controlled trial, the possible antiischemic effect of metoprolol during percutaneous transluminal coronary angioplasty was tested.
Bonnier, J.J.R.M. (Hans) +4 more
core +1 more source
ChemSusChem, Accepted Article.Enantiopure β‐chlorohydrins are valuable intermediates in organic synthesis, acting as chiral building blocks for obtaining biologically active compounds. This work presents a one‐pot two‐step linear sequence for the efficient deracemization of β‐chlorohydrins by combining a photocatalytic alcohol oxidation with a stereoselective carbonyl bioreduction ...
Sara Filgueira +3 more
wiley +1 more source
Metoprolol protects against myocardial infarction by inhibiting miR‐1 expression in rats
The Journal of pharmacy and pharmacology, 2019 Metoprolol is regarded as a first‐line medicine for the treatment of myocardial infarction (MI). However, the underlying mechanisms remain largely unknown.
W. Qin +8 more
semanticscholar +1 more source
Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure. [PDF]
, 2019 BACKGROUND: Moderate and moderately severe renal impairment are common in patients with heart failure and reduced ejection fraction, but whether beta-blockers are effective is unclear, leading to underuse of life-saving therapy.
Andersson, B +22 more
core +8 more sources