Results 71 to 80 of about 26,644 (180)

Metoprolol for prevention of bucking at orotracheal extubation: a double-blind, placebo-controlled randomised trial

Brazilian Journal of Anesthesiology
Background: Respiratory responses to extubation can cause serious postoperative complications. Beta-blockers, such as metoprolol, can interfere with the cough pathway.
Murilo Neves de Queiroz, Fabrício Tavares Mendonça, Maurício Vargas de Matos, Rafael Santos Lino, Luiz Sérgio Fernandes de Carvalho   +4 more
doaj   +1 more source

{2-Hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl}isopropylammonium hemisuccinate

Acta Crystallographica Section E, 2009
Metoprolol, a widely used adrenoreceptor blocking drug, is commonly administered as the succinate or tartrate salt. The structure of metoprolol succinate, C15H26NO3+·0.5C4H4O42−, is characterized by the presence of ribbons in which ...
Gianluca Bartolucci, Bruno Bruni, Silvia A. Coran, Massimo Di Vaira   +3 more
doaj   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, Volume 18, Issue 8, Page 1065-1075, August 2026.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

A Pharmacogenomics‐Guided Antihypertensive Strategy for Blood Pressure Reduction in Rural China: A Cluster‐Randomized Controlled Trial

Health Care Science, Volume 5, Issue 4, Page 353-363, August 2026.
This manuscript reports the findings from the Pharmacogenomic‐guided Antihypertensive Strategy Trial study amidst the deteriorating blood pressure control observed globally during the COVID‐19 pandemic. A pharmacogenomics‐guided strategy achieved a 98.4% blood pressure control rate at 4 weeks in rural China.
Wangjun Qin, Mengke Yu, Ying Zhu, Queran Lin, Limei Yin, Guisheng Liu, Yaping Wang, Guangqiang Lu, Xiaofei Liu, Pengmei Li, Xudong Kong, Li Zhao, Kun Tang, Jiangli Jin, Yu Xiong, Yingnan Zhao, Yan Yan, Bo Li, Azeem Majeed, Xianbo Zuo, Yue Qiu, Jiantuo Yu, Lihong Liu   +22 more
wiley   +1 more source

A higher peak heart rate during head-up tilt test predicts the therapeutic efficacy of metoprolol in vasovagal syncope

BMC Cardiovascular Disorders
Background Although beta blockers, such as metoprolol, have been widely used in the management of vasovagal syncope (VVS), their efficacy remains debated, with larger studies showing limited benefit.
Kemei Liu, Pengyu Liu, Zhuoshan Huang, Lin Wu, Xujing Xie, Jinlai Liu, Jieming Zhu, Yuen Liang, Ruimin Dong   +8 more
doaj   +1 more source

Pacing the Impossible: ICE‐ and Voltage‐Guided Atrial Leadless Pacemaker Implantation in Double Mechanical Valve Disease

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
A and B: Right atrial voltage mapping identified a limited region of viable myocardium within an extensive atrial scar. C: Intracardiac echocardiography guided safe deployment of an atrial leadless pacemaker. D and E: Fluoroscopy confirmed stable device positioning in the right atrial appendage of the patient.
Kridhitach Ngarmukos, Narut Prasitlumkum, Pattara Rattanawong   +2 more
wiley   +1 more source

Graphene Oxide/Polyethylene Glycol-Stick for Thin Film Microextraction of β-Blockers from Human Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2019
A wooden stick coated with a novel graphene-based nanocomposite (Graphene oxide/polyethylene glycol (GO/PEG)) is introduced and investigated for its efficacy in solid phase microextraction techniques.
Hanieh Karimiyan, Mohammad Reza Hadjmohammadi, Karthik Laxman Kunjali, Mohammad Mahdi Moein, Joydeep Dutta, Mohamed Abdel-Rehim   +5 more
doaj   +1 more source

Midterm Efficacy of SubcutAneous Implantable CardioVErter‐Defibrillator in ≤ 18 Year‐Old CHILDREN (SAVE CHILDREN‐II Registry)

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
S‐ICD therapy demonstrated favorable mid‐term safety and efficacy in pediatric patients, with durable sensing performance and a low incidence of device‐related infection. ABSTRACT Background The subcutaneous implantable cardioverter‐defibrillator (S‐ICD) avoids transvenous leads and is a promising option for sudden cardiac death (SCD) prevention in ...
Hitoshi Mori, Taisuke Nabeshima, Kota Nagaoka, Hideo Fukunaga, Hidemori Hayashi, Osamu Inaba, Yuhei Isonaga, So Asano, Junichi Nitta, Shigeo Watanabe, Sou Otsuki, Hiroshi Suzuki, Hidehira Fukaya, Jun Kishihara, Toshiyuki Chisaka, Takashi Higaki, Ayako Okada, Hideki Kobayashi, Takayuki Sekihara, Takafumi Oka, Seiichi Sato, Keisuke Yoshino, Hidekazu Kondo, Naohiko Takahashi, Ken Kato, Masaru Miura, Jun Maeda, Shuntaro Tamura, Kentaro Ikeda, Hiroko Goto, Takashi Murakami, Tsutomu Wada, Motoki Takamuro, Tsugutoshi Suzuki, Yuji Ishida, Shingo Sasaki, Takuro Nishimura, Masateru Takigawa, Tomomi Matsuura, Tomohiko Imamura, Satoshi Shizuta, Masato Fukunaga, Maiko Kuroda, Rintaro Hojo, Seiji Fukamizu, Hirohiko Suzuki, Yukihiko Yoshida, Itsuro Morishima, Kenji Kuraishi, Eiki Nishihara, Yoshihisa Naruse, Tomoyuki Sato, Yoshiyasu Aizawa, Kimitaka Nishizaki, Kentaro Nakamura, Norihito Nuruki, Masao Yoshinaga, Yukitoshi Ikeya, Yasuo Okumura, Shota Muraji, Yusuke Kondo, Makoto Nakano, Machiko Kito, Yasuya Inden, Satoshi Higuchi, Takahiko Kinjo, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Tsukasa Naganuma, Daisuke Kawano, Naomichi Tanaka, Kei Matsumoto, Takuro Kojima, Yoshifumi Ikeda, Ritsushi Kato, Naokata Sumitomo   +76 more
wiley   +1 more source

Medication Burden: Beyond Counts to Recognize Polypharmacy as an Inherent Part of Living With Chronic Kidney Disease

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Medication burden in older patients with chronic kidney disease (CKD) is substantial, and simple medication counts are insufficient for identifying those at elevated risk of inappropriate prescribing. This study characterized medication burden by assessing the number of medications, potentially inappropriate medications (PIMs) and ...
Morten Baltzer Houlind, Helle Gybel Juul‐Larsen, Charlotte Strandhave, Niels Westergaard, Anne Estrup Olesen   +4 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source