Results 81 to 90 of about 31,613 (220)

Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed‐breed dogs, weighing 15.33 ± 2.25 kg, participated in a two‐treatment crossover design: G1 received intravenous dipyrone (25 ...
Andressa Nunes Mouta   +8 more
wiley   +1 more source

Bioanalytical method development and validation for determination of metoprolol tartarate and hydrochlorothiazide using HPTLC in human plasma

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2013
A simple, sensitive, rapid and economic chromatographic method has been developed for determination of metoprolol tartarate and hydrochlorothiazide in human plasma using paracetamol as an internal standard.
Ambadas Ranganath Rote   +1 more
doaj   +1 more source

Effect of metoprolol in patients with renal hypertension [PDF]

open access: yes, 1988
Eighteen patients with renal hypertension were treated with metoprolol (Seloken) for more than 3 months. Compared with the pretreatment value, the mean blood pressure decreased by 6.0, 11.2, 9.2 and 12.2 mmHg, after 2 weeks and 3, 6 and 12 months of ...
西阪, 誠泰   +8 more
core  

Metoprolol v. clonidine in the prophylactic treatment of migraine.

open access: yes, 1985
peer reviewedIn a double-blind, cross-over trial, the migraine prophylactic effect of the beta 1-adrenoceptor antagonist metoprolol was compared with that of clonidine. The dosage of metoprolol was 50 mg b.i.d.
Louis, P., Schoenen, Jean, Hedman, C.
core   +1 more source

Biodegradation of metoprolol in oxic and anoxic hyporheic zone sediments : unexpected effects on microbial communities

open access: yes, 2021
Metoprolol is widely used as a beta-blocker and considered an emerging contaminant of environmental concern due to pseudo persistence in wastewater effluents that poses a potential ecotoxicological threat to aquatic ecosystems.
Posselt, Malte,   +4 more
core   +1 more source

Using an Adapted Job Demands–Resources Model to Examine the Use of Legal, Prescription, and Illegal Drugs for Cognitive Enhancement in the Working Population in Germany

open access: yesSociological Inquiry, EarlyView.
Chronic stress is a global issue with detrimental effects on health and productivity, often leading individuals to adopt health‐related coping strategies. This study uses an adapted Job Demands–Resources model to examine how various job demands and resources impact perceived stress and, consequently, the use of legal, prescription, and illegal drugs ...
Sebastian Sattler   +3 more
wiley   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2203-2211, July 2026.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres   +8 more
wiley   +1 more source

Göteborg Metoprolol Trial : tolerance

open access: yes, 1984
During a 3-month follow-up, 131 patients (19.1%) withdrew from blind treatment in both metoprolol- and placebo-treated groups. More metoprolol-treated than placebo-treated patients withdrew because of cardiovascular adverse experience mainly during the ...
Wilhelmsson, C   +6 more
core  

Image_4_Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug.tif

open access: yes, 2018
Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin.
Benjamin Berger (3704707)   +4 more
core   +1 more source

Chronic Spontaneous Coronary Artery Dissection in a Young Woman Managed With Coronary Artery Bypass Grafting: A Case Report With Literature Review

open access: yesClinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Spontaneous coronary artery dissection (SCAD) is an uncommon, non‐atherosclerotic cause of acute coronary syndrome, typically occurring in young to middle‐aged women. Although most cases resolve spontaneously with conservative therapy, a small proportion develop chronic dissections that require revascularization.
Gashaw Solela   +13 more
wiley   +1 more source

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