Results 71 to 80 of about 680,163 (298)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Metric Dimension for Random Graphs [PDF]

The Electronic Journal of Combinatorics, 2013
The metric dimension of a graph $G$ is the minimum number of vertices in a subset $S$ of the vertex set of $G$ such that all other vertices are uniquely determined by their distances to the vertices in $S$. In this paper we investigate the metric dimension of the random graph $G(n,p)$ for a wide range of probabilities $p=p(n)$.
Bollobás, Béla, Mitsche, Dieter, Prałat, Paweł   +2 more
openaire   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Fault-Tolerant Metric Dimension in Carbon Networks

Foundations
In this paper, we study the fault-tolerant metric dimension in graph theory, an important measure against failures in unique vertex identification. The metric dimension of a graph is the smallest number of vertices required to uniquely identify every ...
Kamran Azhar, Asim Nadeem, Yilun Shang
doaj   +1 more source

A Central Local Metric Dimension of Generalized Fan Graph, Generalized Broken Fan Graph, and Cm ⊙ K¯m [PDF]

E3S Web of Conferences
The central local metric dimension is a new variation of local metric dimension that introduced in 2023. The central local metric dimension is a new concept that enriches research studies in graph theory, especially in the field of metric dimension. This
Listiana Yuni, Susilowati Liliek, Slamin
doaj   +1 more source

Metric Basis of Four-Dimensional Klein Bottle [PDF]

, 2023
Ali N. A. Koam, Ali Ahmad, Maryam Salem Alatawi, Muhammad Azeem, Muhammad Faisal Nadeem   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

On the metric dimensions for sets of vertices

Discussiones Mathematicae Graph Theory, 2020
21 pages, 5 ...
Hakanen, Anni, Junnila, Ville, Laihonen, Tero, Puertas González, María Luz   +3 more
openaire   +5 more sources

Axisymmetric metrics in arbitrary dimensions [PDF]

Classical and Quantum Gravity, 2003
We consider axially symmetric static metrics in arbitrary dimension, both with and without a cosmological constant. The most obvious such solutions have an SO(n) group of Killing vectors representing the axial symmetry, although one can also consider abelian groups which represent a flat `internal space'.
Charmousis, Christos, Gregory, Ruth
openaire   +3 more sources