Results 81 to 90 of about 691,381 (299)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Metric Dimension of Amalgamation of Cycles [PDF]

, 2010
For an ordered set W = {w_1, w_2 , ..., w_k } of vertices and a vertex v in a connected graph G, the representation of v with respect to W is the ordered k-tuple r(v|W) = (d(v,w_1), d(v,w_2 ), ..., d (v,w_k )), where d(x,y) represents the distance ...
Baskoro, Edy Tri, Iswadi, Hazrul, Salman, A.N.M, Simanjuntak, Rinovia   +3 more
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Fault-Tolerant Edge Metric Dimension of Zero-Divisor Graphs of Commutative Rings

Axioms
In recent years, the intersection of algebraic structures and graph-theoretic concepts has developed significant interest, particularly through the study of zero-divisor graphs derived from commutative rings.
Omaima Alshanquiti, Malkesh Singh, Vijay Kumar Bhat   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

On The Local Metric Dimension of Line Graph of Special Graph

Cauchy: Jurnal Matematika Murni dan Aplikasi, 2016
Let G be a simple, nontrivial, and connected graph.  is a representation of an ordered set of k distinct vertices in a nontrivial connected graph G. The metric code of a vertex v, where , the ordered  of k-vector is representations of v with respect to W,
Marsidi Marsidi, Dafik Dafik, Ika Hesti Agustin, Ridho Alfarisi   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Metric Dimensions Of Graphs [PDF]

, 2021
In this article, some kinds of triple belongs to metric dimensions are defined. Some classes of graphs in the matter of these kinds, are studied and the relation amid these kinds are considered. The kind of having equivalency amid these notions and some classes of graphs, is obtained.
openaire   +1 more source