Results 101 to 110 of about 1,385,922 (245)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

On the metric dimension of circulant graphs

open access: yesApplied Mathematics Letters, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Muhammad Imran 0006   +3 more
openaire   +2 more sources

Effective dimension in some general metric spaces

open access: yes, 2014
We introduce the concept of effective dimension for a general metric space. Effective dimension was defined by Lutz in (Lutz 2003) for Cantor space and has also been extended to Euclidean space.
Elvira Mayordomo
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

On the metric dimension, the upper dimension and the resolving number of graphs [PDF]

open access: yes, 2013
This paper deals with three resolving parameters: the metric dimension, the upper dimension and the resolving number. We first answer a question raised by Chartrand and Zhang asking for a characterization of the graphs with equal metric dimension and ...
González Herrera, Antonio   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

On the metric dimension of rotationally-symmetric convex polytopes [PDF]

open access: yes, 2016
Metric dimension is a~generalization of affine dimension to arbitrary metric spaces (provided a resolving set exists). Let $\mathcal{F}$ be a family of connected graphs $G_{n}$ : $\mathcal{F} = (G_{n})_{n}\geq 1$ depending on $n$ as follows: the order ...
Haq Bokhary, Syed Ahtsham Ul   +2 more
core  

The hyperbolic dimension of metric spaces [PDF]

open access: yes, 2007
We introduce a new quasi-isometry invariant of metric spaces called the hyperbolic dimension, hypdim, which is a version of the Gromov's asymptotic dimension, asdim.
Schroeder, Viktor   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Metric dimension and equivalent metrics [PDF]

open access: yesFundamenta Mathematicae, 1968
Roberts, J. H., Slaughter, F. G. jun.
openaire   +1 more source

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