Results 61 to 70 of about 727,489 (238)

The Split Feasibility Problem with Some Projection Methods in Banach Spaces

Abstract and Applied Analysis, 2020
In this paper, we study the split feasibility problem in Banach spaces. At first, we prove that a solution of this problem is a solution of the equivalent equation defined by using a metric projection, a generalized projection, and sunny generalized ...
Toshiharu Kawasaki, Hiroko Manaka
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Submaximal metric projective and metric affine structures

Differential Geometry and its Applications, 2014
We prove that the next possible dimension after the maximal $n^2+2n$ for the Lie algebra of local projective symmetries of a metric on a manifold of dimension $n>1$ is $n^2-3n+5$ if the signature is Riemannian or $n=2$, $n^2-3n+6$ if the signature is Lorentzian and $n>2$, and $n^2-3n+8$ elsewise. We also prove that the Lie algebra of local affine
Kruglikov, Boris, Matveev, Vladimir
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A New Hybrid Algorithm for λ-Strict Asymptotically Pseudocontractions in 2-Uniformly Smooth Banach Spaces

Abstract and Applied Analysis, 2012
A new hybrid projection algorithm is considered for a λ-strict asymptotically pseudocontractive mapping. Using the metric projection, a strong convergence theorem is obtained in a uniformly convex and 2-uniformly smooth Banach spaces.
Xin-dong Liu, Shih-sen Chang
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Strong Convergence Theorems for a Finite Family of λi-Strict Pseudocontractions in 2-Uniformly Smooth Banach Spaces by Metric Projections

Journal of Applied Mathematics, 2012
A new hybrid projection algorithm is considered for a finite family of λi-strict pseudocontractions. Using the metric projection, some strong convergence theorems of common elements are obtained in a uniformly convex and 2-uniformly smooth Banach space ...
Xin-dong Liu, Shih-sen Chang, Xiong-rui Wang   +2 more
doaj   +1 more source

The left-invariant contact metric structure on the Sol manifold

Учёные записки Казанского университета: Серия Физико-математические науки, 2020
Among the known eight-dimensional Thurston geometries, there is a geometry of the Sol manifold – a Lie group consisting of real special matrices. For a left-invariant Riemannian metric on the Sol manifold, the left shift group is a maximal simple ...
V.I. Pan’zhenskii, A.O. Rastrepina
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source