Results 31 to 40 of about 467,435 (242)

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk   +10 more
wiley   +1 more source

On RG-spaces and the regularity degree

open access: yesApplied General Topology, 2006
We continue the study of a lattice-ordered ring G(X), associated with the ring C(X). Following, X is called RG when G(X) = C(Xδ). An RG-space must have a dense set of very weak P-points.
R. Raphael, R.G. Woods
doaj   +1 more source

A sufficient condition for metric subregularity of set-valued mappings between Asplund spaces based on an outer-coderivative-like variational tool

open access: yesHeliyon, 2023
In this study, we examine the Generalized Equations' subregularity in Asplund spaces utilizing a novel approach. We obtain sufficient conditions for a family of multifunctions to be metrically subregular which are stronger than the known sufficient ...
Matthieu Maréchal
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Local linear approach: Conditional density estimate for functional and censored data

open access: yesDemonstratio Mathematica, 2022
Let YY be a random real response, which is subject to right censoring by another random variable CC. In this paper, we study the nonparametric local linear estimation of the conditional density of a scalar response variable and when the covariable takes ...
Benkhaled Abdelkader, Madani Fethi
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

A Generalization of Fixed-Point Theorems for Mappings with a Contractive Iterate

open access: yesMathematics
In this paper, a generalization of fixed-point mappings with an iterate at a point in complete metric spaces is shown, using the notions of T-closed sets and i-P-regularity/d-P-regularity, proving conditions for the existence and uniqueness of the fixed ...
Valentin Georgiev, Boyan Zlatanov
doaj   +1 more source

Harmonic Coordinates for the Nonlinear Finsler Laplacian and Some Regularity Results for Berwald Metrics

open access: yesAxioms, 2019
We prove existence of harmonic coordinates for the nonlinear Laplacian of a Finsler manifold and apply them in a proof of the Myers−Steenrod theorem for Finsler manifolds.
Erasmo Caponio, Antonio Masiello
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Hölder metric regularity of set-valued maps

open access: yes, 2012
International audienceThis paper is devoted to metric regularity of set-valued maps from a complete metric space to a Banach space. In particular we extend a known characterization of the regularity modulus to maps defined on reflexive spaces. The higher
Quincampoix, Marc, Frankowska, Hélène
core   +1 more source

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