Results 51 to 60 of about 10,697 (290)

A Generalization of Fixed-Point Theorems for Mappings with a Contractive Iterate

open access: yesMathematics
In this paper, a generalization of fixed-point mappings with an iterate at a point in complete metric spaces is shown, using the notions of T-closed sets and i-P-regularity/d-P-regularity, proving conditions for the existence and uniqueness of the fixed ...
Valentin Georgiev, Boyan Zlatanov
doaj   +1 more source

A sufficient condition for metric subregularity of set-valued mappings between Asplund spaces based on an outer-coderivative-like variational tool

open access: yesHeliyon, 2023
In this study, we examine the Generalized Equations' subregularity in Asplund spaces utilizing a novel approach. We obtain sufficient conditions for a family of multifunctions to be metrically subregular which are stronger than the known sufficient ...
Matthieu Maréchal
doaj   +1 more source

Metric regularity and systems of generalized equations

open access: yes, 2008
The paper is devoted to a revision of the metric regularity property for mappings between metric or Banach spaces. Some new concepts are introduced: uniform metric regularity and metric multi-regularity for mappings into product spaces, when each ...
Kruger, Alexander Y.   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Harmonic Coordinates for the Nonlinear Finsler Laplacian and Some Regularity Results for Berwald Metrics

open access: yesAxioms, 2019
We prove existence of harmonic coordinates for the nonlinear Laplacian of a Finsler manifold and apply them in a proof of the Myers−Steenrod theorem for Finsler manifolds.
Erasmo Caponio, Antonio Masiello
doaj   +1 more source

On well-posedness and algebraic type of the five-dimensional charged rotating black hole with two equal-magnitude angular momenta

open access: yesEuropean Physical Journal C: Particles and Fields, 2022
We study various mathematical aspects of the charged rotating black hole with two equal-magnitude angular momenta in five dimensions. We introduce a coordinate system that is regular on the horizon and in which Einstein–Maxwell equations reduce to an ...
Markus B. Fröb   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A Primer on Carnot Groups: Homogenous Groups, Carnot-Carathéodory Spaces, and Regularity of Their Isometries

open access: yesAnalysis and Geometry in Metric Spaces, 2018
Carnot groups are distinguished spaces that are rich of structure: they are those Lie groups equipped with a path distance that is invariant by left-translations of the group and admit automorphisms that are dilations with respect to the distance.
Le Donne Enrico
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Rigidez métrica e expressividade na interpretação musical: uma teoria neuropsicológica

open access: yesOpus, 2007
Rubato has always been related to musical performance expressivity. In the last 150 years, however, Western art music teaching has emphasized strict metric regularity in the performance of pieces composed before the Romantic era. Such practice however is
Marcia Kazue Kodama Higuchi   +1 more
doaj  

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